Doxy 100 Dosage

Generic name: doxycycline hyclate
Dosage form: injection, powder, lyophilized, for solution

This dosage information does not include all the information needed to use Doxy 100 safely and effectively. See full prescribing information for Doxy 100.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

NOTE:  Rapid administration is to be avoided.  Parenteral therapy is indicated only when oral therapy is not indicated.  Oral therapy should be instituted as soon as possible.  If intravenous therapy is given over prolonged periods of time, thrombophlebitis may result.

THE USUAL DOSAGE AND FREQUENCY OF ADMINISTRATION OF DOXYCYCLINE FOR INJECTION (100 to 200 MG/DAY) DIFFERS FROM THAT OF THE OTHER TETRACYCLINES (1 to 2 G/DAY).  EXCEEDING THE RECOMMENDED DOSAGE MAY RESULT IN AN INCREASED INCIDENCE OF SIDE EFFECTS.

Studies to date have indicated that doxycycline hyclate at the usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal impairment.

Adults

The usual dosage of doxycycline for injection is 200 mg on the first day of treatment administered in one or two infusions.  Subsequent daily dosage is 100 to 200 mg depending upon the severity of infection, with 200 mg administered in one or two infusions.

In the treatment of primary and secondary syphilis, the recommended dosage is 300 mg daily for at least 10 days.

In the treatment of inhalational anthrax (post-exposure) the recommended dose is 100 mg of doxycycline, twice a day.  Parenteral therapy is only indicated when oral therapy is not indicated and should not be continued over a prolonged period of time.  Oral therapy should be instituted as soon as possible.  Therapy must continue for a total of 60 days.

For Children Above Eight Years of Age

The recommended dosage schedule for children weighing 100 pounds or less is 2 mg/lb of body weight on the first day of treatment, administered in one or two infusions.  Subsequent daily dosage is 1 to 2 mg/lb of body weight given as one or two infusions, depending on the severity of the infection.  For children over 100 pounds the usual adult dose should be used (see WARNINGS, Usage in Children).

In the treatment of inhalational anthrax (post-exposure) the recommended dose is 1 mg/lb (2.2 mg/kg) of body weight, twice a day in children weighing less than 100 lb (45 kg).  Parenteral therapy is only indicated when oral therapy is not indicated and should not be continued over a prolonged period of time.  Oral therapy should be instituted as soon as possible.  Therapy must continue for a total of 60 days.

General

The duration of infusion may vary with the dose (100 to 200 mg/day), but is usually one to four hours.  A recommended minimum infusion time for 100 mg of a 0.5 mg/mL solution is one hour.  Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided.  The therapeutic antibacterial serum activity will usually persist for 24 hours following recommended dosage.

Intravenous solutions should not be injected intramuscularly or subcutaneously.  Caution should be taken to avoid the inadvertent introduction of the intravenous solution into the adjacent soft tissue.

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