Dorzolamide/Timolol Ophthalmic Dosage

Usual Adult Dose for Intraocular Hypertension

Instill 1 drop into the affected eye(s) twice daily.

Usual Adult Dose for Glaucoma (Open Angle)

Instill 1 drop into the affected eye(s) twice daily.

Usual Pediatric Dose for Intraocular Hypertension

2 years or older:
Instill 1 drop into the affected eye(s) twice daily.

Usual Pediatric Dose for Glaucoma (Open Angle)

2 years or older:
Instill 1 drop into the affected eye(s) twice daily.

Renal Dose Adjustments

Not recommended for patients with severe renal impairment (CrCl less than 30 mL/min).

Liver Dose Adjustments

Caution is recommended in patients with hepatic impairment.

Precautions

Remove contact lenses before administration and wait at least 15 minutes before reinserting them.

Wait at least 10 minutes before instilling other eyedrops.

Patients should be instructed to avoid allowing the tip of the container to contact the eye, eyelid, fingers or any other surface.

The drug should be discontinued immediately at the first appearance of signs of hypersensitivity or other serious reactions.

Patients should be advised to notify their physician immediately and discontinue the drug if they experience ocular reactions, especially conjunctivitis and lid reactions. Patients should also be advised to contact their physician immediately if they develop other ocular conditions (e.g., infection, trauma), or have eye surgery.

The safety and effectiveness has not been established in pediatric patients less than 2 years of age.

Dorzolamide is a sulfonamide and although administered topically is absorbed systemically. Therefore the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration. Patients should be advised that if serious or unusual reactions including severe skin reactions or signs of hypersensitivity occur, they should discontinue the use of the product.

Dialysis

Not recommended for patients with severe renal impairment (CrCl less than 30 mL/min).

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