Disopyramide Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Arrhythmias

400-800 mg/day. The recommended dose for most adults is 600 mg/day. Patients < 50 kg may be given 400 mg/day.
Immediate-release form: The dose is divided and administered every 6 hours.
Extended-release form: The dose is divided and administered every 12 hours.

Renal Dose Adjustments

Immediate-release:
CrCl < 15 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 24 hours.

CrCl 15-30 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 12 hours.

CrCl 30-40 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 8 hours.

CrCl > 40 mL/min: Loading dose: 200 mg orally.
Maintenance dose: 100 mg orally every 6 hours.

Extended-release:
CrCl <= 40 mL/min: not recommended
CrCl > 40 mL/min: Maintenance dose: 200 mg (extended-release) orally every 12 hours.

Liver Dose Adjustments

Loading dose: 200 mg orally.
Maintenance dose: 100 mg (immediate-release) orally every 6 hours or 200 mg (extended-release) orally every 12 hours.

Dose Adjustments

If rapid control of ventricular arrhythmia is necessary, an initial loading dose of 300 mg of immediate-release, or 200 mg if patient is < 50 kg is recommended.

Patients with cardiomyopathy should not be given a loading dose and should initially receive 100 mg immediate-release every 6 to 8 hours.

Dialysis

Data not available

Other Comments

A limited number of patients have tolerated up to 400 mg orally every 6 hours.

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