Disopyramide Dosage
This dosage information may not include all the information needed to use Disopyramide safely and effectively. See additional information for Disopyramide.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Arrhythmias
400-800 mg/day. The recommended dose for most adults is 600 mg/day. Patients < 50 kg may be given 400 mg/day.
Immediate-release form: The dose is divided and administered every 6 hours.
Extended-release form: The dose is divided and administered every 12 hours.
Renal Dose Adjustments
Immediate-release:
CrCl < 15 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 24 hours.
CrCl 15-30 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 12 hours.
CrCl 30-40 mL/min: Loading dose: 150 mg orally.
Maintenance dose: 100 mg orally every 8 hours.
CrCl > 40 mL/min: Loading dose: 200 mg orally.
Maintenance dose: 100 mg orally every 6 hours.
Extended-release:
CrCl <= 40 mL/min: not recommended
CrCl > 40 mL/min: Maintenance dose: 200 mg (extended-release) orally every 12 hours.
Liver Dose Adjustments
Loading dose: 200 mg orally.
Maintenance dose: 100 mg (immediate-release) orally every 6 hours or 200 mg (extended-release) orally every 12 hours.
Dose Adjustments
If rapid control of ventricular arrhythmia is necessary, an initial loading dose of 300 mg of immediate-release, or 200 mg if patient is < 50 kg is recommended.
Patients with cardiomyopathy should not be given a loading dose and should initially receive 100 mg immediate-release every 6 to 8 hours.
Dialysis
Data not available
Other Comments
A limited number of patients have tolerated up to 400 mg orally every 6 hours.
