Diphtheria Toxoid / Tetanus Toxoid Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diphtheria Prophylaxis

2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.

A booster dose is recommended every 10 years.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Adult Dose for Tetanus Prophylaxis

2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.

A booster dose is recommended every 10 years.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Pediatric Dose for Diphtheria Prophylaxis

7 years and older:
Primary Immunization:
2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.
Booster Immunization:
Children 11 to 12 years: A single dose when at least 5 years have elapsed since last dose of toxoid containing vaccine.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose.

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Pediatric Dose for Tetanus Prophylaxis

7 years and older:
Primary Immunization:
2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.
Booster Immunization:
Children 11 to 12 years: A single dose when at least 5 years have elapsed since last dose of toxoid containing vaccine.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose.

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

DT is indicated for patients less than 7 years; Td should be used in patients 7 years and older. Verify the product age indications prior to administration.

For IM administration only. Preferred sites of administration are the anterolateral aspect of thigh or deltoid muscle of the upper arm.

Dialysis

Data not available

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