Dihydrotachysterol Dosage

Usual Adult Dose for Hypocalcemia

Initial dose: 0.25 to 0.8 mg orally once a day for several days.
Maintenance dose: 0.2 to 1 mg orally once a day.

Usual Adult Dose for Hypoparathyroidism

Initial dose: 0.8 to 2.4 mg orally once a day for 4 days.
Maintenance dose: 0.2 to 1 mg orally once a day.

Usual Adult Dose for Hypophosphatemia

Initial dose: 0.8 to 2.4 mg orally once a day for several days.
Maintenance dose: 0.2 to 1 mg orally once a day.

Usual Adult Dose for Osteoporosis

0.6 mg orally once a day. Has been used in conjunction with fluoride and calcium.

Usual Adult Dose for Renal Osteodystrophy

0.1 to 0.6 mg orally once a day.

Usual Adult Dose for Rickets

0.5 mg orally one time or 13 to 50 mcg/day until healing occurs.

Usual Pediatric Dose for Hypoparathyroidism

Neonate Dose: 0.05 to 0.1 mg orally once a day.

Infant and Child Dose:
Initial dose: 1 to 5 mg orally once a day for 4 days.
Maintenance dose: 0.5 to 1.5 mg orally once a day.

Usual Pediatric Dose for Renal Osteodystrophy

0.1 to 0.5 mg orally once a day.

Usual Pediatric Dose for Rickets

0.5 mg orally one time or 13 to 50 mcg/day until healing occurs.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

May increase at 4 to 8 week intervals.

Precautions

Dihydrotachysterol should be withheld if hypercalcemia develops.

Dialysis

Vitamin D and its metabolites are not dialyzable.

Other Comments

Patients should receive adequate calcium during dihydrotachysterol therapy. Serum calcium should be monitored 1 to 2 times a week during dosage titration, and approximately once a month after stabilization. Serum calcium levels should be maintained between 9 to 10 mg/dL.

See also...