Diclofenac Dosage

This dosage information may not include all the information needed to use Diclofenac safely and effectively. See additional information for Diclofenac.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Osteoarthritis

Diclofenac: 50 mg orally 2 to 3 times a day or 75 mg orally twice a day. Doses greater than 150 mg/day are not recommended for osteoarthritis.

Diclofenac Extended-release: 100 mg orally once a day.

Usual Adult Dose for Ankylosing Spondylitis

Diclofenac Sodium: 25 mg orally 4 times a day. An additional 25 mg dose may be administered at bedtime, if necessary.

Usual Adult Dose for Dysmenorrhea

Diclofenac Potassium: 50 mg orally 3 times a day. In some patients an initial dose of 100 mg of diclofenac potassium, followed by 50 mg doses, will provide better relief. After the first day, the total daily dose should generally not exceed 150 mg.

Diclofenac Potassium liquid filled capsules (Zipsor[R]) are only approved by the FDA for mild to moderate acute pain. The dosage for this product is 25 mg orally 4 times a day.

Usual Adult Dose for Pain

Diclofenac Potassium: 50 mg orally 3 times a day. In some patients an initial dose of 100 mg of diclofenac potassium, followed by 50 mg doses, will provide better relief. After the first day, the total daily dose should generally not exceed 150 mg.

Diclofenac Potassium liquid filled capsules (Zipsor[R]) are only approved by the FDA for mild to moderate acute pain. The dosage for this product is 25 mg orally 4 times a day.

Usual Adult Dose for Rheumatoid Arthritis

Diclofenac: 50 mg orally 3 to 4 times a day or 75 mg orally twice a day.

Diclofenac Extended-release: 100 mg orally once a day.

Doses greater than 225 mg/day are not recommended for rheumatoid arthritis.

Usual Adult Dose for Migraine

For acute treatment of migraine without aura:

Diclofenac potassium for oral solution packets: Mix one packet (50 mg) with 1 to 2 ounces (30 to 60 mL) water in a cup and drink immediately.

Usual Pediatric Dose for Pain

Children: 2 to 3 mg/kg/day orally in divided doses 2 to 4 times daily
Maximum dose: 200 mg daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

In patients weighing less than 60 kg, or where the severity of the disease, concomitant medication, or other diseases warrant, the maximum recommended total daily dose should be reduced.

Precautions

Different formulations of diclofenac may not be bioequivalent even if the milligram strength is the same. Therefore, it is not possible to convert from one diclofenac formulation to another.

Diclofenac potassium for oral solution packets contain aspartame equivalent to phenylalanine 25 mg per packet.

According to the manufacturer, safety and effectiveness of diclofenac in pediatric patients (less than 18 years of age) have not been established.

Dialysis

Data not available

Other Comments

If no improvement is seen within 2 to 4 weeks of therapy, an alternative NSAID should be considered.

Because serious hepatotoxicity may not be preceded by characteristic syndromes, it is recommended that liver function tests be monitored periodically during therapy.

Diclofenac potassium for oral solution packets are not indicated for the prophylactic therapy of migraine, and safety and effectiveness have not been established for cluster headache, which is present in an older, predominately male population.

Do not mix diclofenac potassium for oral solution packets with liquids other than water.

Taking diclofenac potassium for oral solution packets with food may cause a reduction in effectiveness compared to taking it on an empty stomach.

Diclofenac potassium for oral solution packets should only be taken as a single dose. Safety and effectiveness of a second dose have not been established.

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