Diclofenac / Misoprostol Dosage

This dosage information may not include all the information needed to use Diclofenac / Misoprostol safely and effectively. See additional information for Diclofenac / Misoprostol.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Osteoarthritis

Diclofenac 50 mg/misoprostol 200 mg: 1 tablet orally 3 times daily.

For patients who experience intolerance, diclofenac 75 mg/misoprostol 200 mg orally 2 times daily or diclofenac 50 mg/misoprostol 200 mg orally 2 times daily can be used, but are less effective in preventing ulcers.

Usual Adult Dose for Rheumatoid Arthritis

Diclofenac 50 mg/misoprostol 200 mg: 1 tablet orally 3 to 4 times daily.

For patients who experience intolerance, diclofenac 75 mg/misoprostol 200 mg orally 2 times daily or diclofenac 50 mg/misoprostol 200 mg orally 2 times daily can be used, but are less effective in preventing ulcers.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Diclofenac-misoprostol contains misoprostol, which provides protection against gastric and duodenal ulcers. For gastric ulcer prevention, the 200 mcg 3 or 4 times daily regimens are therapeutically equivalent, but more protective than the 2 times daily regimen. For duodenal ulcer prevention, the 4 times daily regimen is more protective than the 2 or 3 times daily regimens. However, the 4 times daily regimen is less well tolerated than the 3 times daily regimen because of usually self-limited diarrhea related to the misoprostol, and the 2 times daily regimen may be better tolerated than 3 times daily in some patients.

Dialysis

Data not available

Other Comments

The fixed combination product, diclofenac-misoprostol, is not recommended for patients who would not receive the appropriate dose of both ingredients.

Misoprostol may cause diarrhea. Dosage may be individualized using the separate drugs. For gastric ulcer prevention, the 200 mcg four times/day and three times/day schedules are therapeutically equivalent, but more protective than the twice daily regimen. For duodenal ulcer prevention, the four times/day regimen is more protective than the three times/day regimen.

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