Diazoxide Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypertensive Emergency

IV: 1 to 3 mg/kg up to a maximum of 150 mg every 5 to 15 minutes, then every 4 to 24 hours. It should be administered in less than 30 seconds into a peripheral vein.

Usual Adult Dose for Hypoglycemia

3 to 8 mg/kg/day orally in divided doses every 8 or 12 hours. Higher dosages (up to 15 mg/kg/day) have been used in refractory hypoglycemia.

Usual Pediatric Dose for Hypertensive Emergency

1 to 5 mg/kg IV up to a maximum of 150 mg every 5 to 15 minutes, then every 4 to 24 hours. The dose should be administered in less than 30 seconds into a peripheral vein. Alternatively, 3 to 5 mg/kg infused over 30 minutes may result in less hypotension and hyperglycemia.

Usual Pediatric Dose for Hypoglycemia

Hyperinsulinemic hypoglycemia:
less than 1 month: Initial: 10 mg/kg/day orally in divided doses every 8 hours; usual range: 5 to 15 mg/kg/day orally in divided doses every 8 hours
less than 1 year: Initial: 10 mg/kg/day orally in divided doses every 8 hours; usual range: 5 to 20 mg/kg/day orally in divided doses every 8 hours
1 year or older: Initial: 3 mg/kg/day orally in divided doses every 8 hours; usual range: 3 to 8 mg/kg/day orally in divided doses every 8 to 12 hours

Higher dosages (up to 15 mg/kg/day) have been used in refractory hypoglycemia.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The IV dose may be repeated at 5 to 15 minute intervals until blood pressure control has been achieved. It is usually unnecessary to continue for more than 5 days. Do not use for more than 10 days.

Precautions

Intravenous administration may produce a large decrease in blood pressure. Blood pressure should be monitored closely until it stabilizes and at least hourly thereafter.

Diazoxide causes sodium retention and is ineffective in pheochromocytoma.

Dialysis

Data not available

Other Comments

Do not use in patients allergic to thiazides or other sulfonamide derivatives.

Hide
(web4)