Desloratadine/Pseudoephedrine Dosage

Usual Adult Dose for Allergic Rhinitis

desloratadine-pseudoephedrine 2.5 mg-120 mg oral tablet, extended release:
one extended release tablet orally twice daily, administered approximately 12 hours apart

desloratadine-pseudoephedrine 5 mg-240 mg oral tablet, extended release:
one extended release tablet orally once daily

Usual Pediatric Dose for Allergic Rhinitis

12 yrs or older:
desloratadine-pseudoephedrine 2.5 mg-120 mg oral tablet, extended release:
one extended release tablet orally twice daily, administered approximately 12 hours apart

desloratadine-pseudoephedrine 5 mg-240 mg oral tablet, extended release:
one extended release tablet orally once daily

Renal Dose Adjustments

The manufacturer recommends that desloratadine-pseudoephedrine should generally be avoided in patients with renal impairment.

Liver Dose Adjustments

The manufacturer recommends that desloratadine-pseudoephedrine should generally be avoided in patients with hepatic insufficiency.

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

Dialysis

Pseudoephedrine is partially removed by hemodialysis, therefore doses should be given following dialysis sessions.

See also...