Skip to Content

Depo-SubQ Provera 104 Dosage

Generic name: medroxyprogesterone acetate
Dosage form: injection, suspension

See also:

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.


Route of Administration

depo-subQ provera 104 must be given by subcutaneous injection into the anterior thigh or abdomen, once every 3 months (12 to 14 weeks). depo-subQ provera 104 is not formulated for intramuscular injection. Dosage does not need to be adjusted for body weight. The pre-filled syringe of depo-subQ provera 104 must be vigorously shaken just before use to create a uniform suspension.

First Injection

Ensure that the patient is not pregnant at the time of the first injection. For women who are sexually active and having regular menses, the first injection should be given only during the first 5 days of a normal menstrual period. Women who are breast-feeding may have their first injection during or after their sixth postpartum week.

Second and Subsequent Injections

Dosing is every 12 to 14 weeks. If more than 14 weeks elapse between injections, pregnancy should be ruled out before the next injection.


When switching from other contraceptive methods, depo-subQ provera 104 should be given in a manner that ensures continuous contraceptive coverage. For example, patients switching from combined (estrogen plus progestin) contraceptives should have their first injection of depo-subQ provera 104 within 7 days after the last day of using that method (7 days after taking the last active pill, removing the patch or ring). Similarly, contraceptive coverage will be maintained in switching from Depo-Provera CI (150 mg) to depo-subQ provera 104, provided the next injection is given within the prescribed dosing period for Depo-Provera CI (150 mg).


Treatment for longer than two years is not recommended, due to the impact of long-term depo-subQ provera 104 on bone mineral density. If symptoms return after discontinuation of treatment, bone mineral density should be evaluated prior to retreatment.

Instructions for Use of depo-subQ provera 104


Please read these instructions carefully. It is very important that the entire dose of depo-subQ provera 104 is given.

Getting ready

Do not refrigerate. Ensure that the medication is at room temperature prior to injection (to ensure appropriate viscosity of the suspension). Make sure the following components are available.


depo-subQ provera 104, as with other parenteral drug products, should be inspected visually for particulate matter and discoloration prior to administration.

Step 1: Choosing & preparing the injection Area

Choose the injection area.
  • Avoid boney areas and the umbilicus
  • The upper thigh or abdomen are preferred injection sites. See shaded areas in diagram
Preferred injection areas:
                Upper thigh or abdomen
Use an alcohol pad to wipe the skin in the injection area you have chosen.
  • Allow the skin to dry

Step 2: Syringe preparation

Carefully remove the needle and syringe from the packaging.
Hold the syringe firmly by the barrel, with the barrel pointing upward.
  • Shake it vigorously for at least 1 minute to thoroughly mix the medication
Hold the syringe barrel firmly.
  • Remove the protective cap from the tip of the syringe barrel
Shake vigorously for 1 minute
Hold the syringe barrel firmly.
  • Attach the needle to the barrel of the syringe firmly by pushing the plastic needle cover down fully with a slight twisting movement.
  • Move the safety shield away from the needle and toward the syringe barrel. The safety shield will remain in an open 45 to 90 degree position
  • While holding the syringe barrel firmly, remove the plastic needle cover from the needle without twisting, ensuring the needle is still firmly attached to the syringe
  • While holding the syringe with the needle pointing upward, gently push in the plunger until the medicine is up to the top of the syringe. There should be no air within the barrel

Step 3: Injecting the dose

Gently grasp and squeeze a large area of skin in the chosen injection area between the thumb and forefinger, pulling it away from the body. Figure
Insert the needle at a 45 degree angle so that most of the needle is in the fatty tissue.
  • The plastic hub of the needle should be nearly or almost touching the skin
Inject the medication slowly until the syringe is empty.
  • This should take about 5–7 seconds
  • It is important that the entire dose of depo-subQ provera 104 is given
                    Inject slowly
                    (5–7 seconds)


Step 4: Disposing the needle and syringe

After completing the injection, remove the needle from the skin and activate the safety shield. Figure
Position shield about 40°– 45°. With a firm quick motion, press down against a flat surface until a click is heard or felt.  
If uncertain that the safety shield is fully engaged, repeat this step.  
Use a clean cotton pad to press lightly on the injection area for a few seconds.
  • Do NOT rub the area
Following the administration of each dose, the used syringe should be discarded in a safe and proper manner.
Keep away from children.