Daunorubicin Liposomal Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Kaposi's Sarcoma

For first line cytotoxic therapy for advanced HIV-associated Kaposi's sarcoma. (Note: Daunorubicin liposomal is not recommended for use in patients with less than advanced HIV-related Kaposi's sarcoma.

If the patient has an acceptable benefit-cardiac risk ratio and adequate blood cell counts, then the recommended dose is: 40 mg/m2 infused intravenously over 60 minutes every 2 weeks,

Renal Dose Adjustments

If the serum creatinine is >3 mg/dL, then 1/2 of the normal dose is recommended

Liver Dose Adjustments

If the serum bilirubin is 1.2 to 3 mg/dL, then 3/4 of the normal dose is recommended.

If the serum bilirubin is >3 mg/dL, then 1/2 of the normal dose is recommended

Precautions

Safety has not been established in patients with pre-existing renal or hepatic dysfunction.

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