Generic name: propoxyphene napsylate and acetaminophen
Dosage form: tablet
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Darvocet-N is intended for the management of mild to moderate pain. The dose should be individually adjusted according to severity of pain, patient response and patient size.
Darvocet-N 100 (100 mg propoxyphene napsylate and 650 mg acetaminophen)
The usual dosage is one tablet every 4 hours orally as needed for pain. The maximum dose of DARVOCET-N 100 is 6 tablets per day. Do not exceed the maximum daily dose.
Darvocet-N 50 (50 mg propoxyphene napsylate and 325 mg acetaminophen)
The usual dosage is two tablets every 4 hours orally as needed for pain. The maximum dose of DARVOCET-N 50 is 12 tablets per day. Do not exceed the maximum daily dose.
Patients receiving propoxyphene and any CYP3A4 inhibitor should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted.
Consideration should be given to a reduced total daily dosage in elderly patients and in patients with hepatic or renal impairment.
Cessation of Therapy
For patients who used Darvocet-N on a regular basis for a period of time, when therapy with Darvocet-N is no longer needed for the treatment of their pain, it may be useful to gradually discontinue the Darvocet-N over time to prevent the development of an opioid abstinence syndrome (narcotic withdrawal). In general, therapy can be decreased by 25% to 50% per day with careful monitoring for signs and symptoms of withdrawal (see DRUG ABUSE AND DEPENDENCE for description of the signs and symptoms of withdrawal). If the patient develops these signs or symptoms, the dose should be raised to the previous level and titrated down more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both.