Medication Guide App

Darifenacin Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Urinary Incontinence

Initial dose: 7.5 mg orally once daily with liquid

The dosage may be increased to 15 mg orally once daily two weeks after starting therapy.

Usual Adult Dose for Urinary Frequency

Initial dose: 7.5 mg orally once daily with liquid

The dosage may be increased to 15 mg orally once daily two weeks after starting therapy.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild hepatic impairment: No adjustment recommended
Moderate hepatic impairment: Not to exceed 7.5 mg orally once daily
Severe hepatic impairment: Not recommended

Dose Adjustments

Do not exceed 7.5 mg orally once daily when coadministered with potent CYP450 3A4 inhibitors.

Precautions

Darifenacin is contraindicated for use in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions.

Caution should be exercised when using darifenacin in patients with clinically significant bladder outflow obstruction because of the risk of urinary retention.

Similar to other drugs with anticholinergic activity, caution should be used in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Darifenacin may decreased gastrointestinal motility and should be used with caution in patients with conditions such as severe constipation, ulcerative colitis, and myasthenia gravis.

Darifenacin should be administered with caution in patients being treated for narrow-angle glaucoma and only where the potential benefits outweigh the risks.

Darifenacin is not recommended for use in patients with severe hepatic impairment.

Heat prostration may occur when anticholinergic drugs, such as darifenacin, are used in hot weather because of their action on the sweat glands.

Anticholinergics, such as darifenacin, may produce dizziness or blurred vision. Patients should be advised to use caution in decisions to engage in potentially dangerous activities.

The safety and effectiveness of darifenacin in pediatric patients has not been determined.

Dialysis

Data not available

Other Comments

Darifenacin may be taken with or without food. The tablet should be swallowed whole.

The manufacturer recommends against dividing or crushing the extended release tablet.

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