Dalfampridine Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Multiple Sclerosis

Maximum recommended dose: 10 mg every 12 hours, taken with or without food

Patients should not take double or extra doses if a dose is missed.

Tablets should only be taken whole. Tablets should not be divided, crushed, chewed, or dissolved.

Usual Geriatric Dose for Multiple Sclerosis

Maximum recommended dose: 10 mg every 12 hours, taken with or without food

Patients should not take double or extra doses if a dose is missed.

Tablets should only be taken whole. Tablets should not be divided, crushed, chewed, or dissolved.

A population pharmacokinetic analysis showed that dalfampridine clearance modestly decreased with increasing age, but not sufficiently to necessitate a modification of dose.

Renal Dose Adjustments

Dalfampridine is contraindicated in patients with moderate or severe renal impairment (CrCl less than or equal to 50 mL/min). The risk of seizures in patients with mild renal impairment (CrCl 51 to 80 mL/min) is unknown, but dalfampridine plasma levels in these patients may approach those seen at a dose of 15 mg twice daily, a dose that may be associated with an increased risk of seizures.

Liver Dose Adjustments

The pharmacokinetics of dalfampridine in hepatically impaired subjects has not been studied. Since dalfampridine is primarily excreted unchanged in the urine, hepatic impairment is not expected to significantly affect dalfampridine pharmacokinetics or recommended dosing.

Dose Adjustments

A population pharmacokinetic analysis suggested that female patients would be expected to have higher maximum dalfampridine plasma concentration than male patients. The magnitude of these differences is small and does not necessitate any dose modification.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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