Cytarabine Dosage

This dosage information may not include all the information needed to use Cytarabine safely and effectively. See additional information for Cytarabine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Acute Nonlymphocytic Leukemia

As a part of a combination chemotherapy:
100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7) with an anthracycline.

Usual Adult Dose for non-Hodgkin's Lymphoma

Acute Leukemia Induction:
100 to 200 mg/m2/day or 2 to 6 mg/kg/day as a continuous IV infusion over 24 hours or in divided doses by rapid injection for 5 to 10 days. This course may be repeated approximately every 2 weeks.


For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
2 to 3 g/m2 IV every twelve hours for up to 12 doses. The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.


For chronic granulocytic leukemia / chronic myelogenous leukemia:
20 mg/m2 subcutaneously for 10 days per month for 6 months with interferon alfa.

Usual Adult Dose for Chronic Myelogenous Leukemia

Acute Leukemia Induction:
100 to 200 mg/m2/day or 2 to 6 mg/kg/day as a continuous IV infusion over 24 hours or in divided doses by rapid injection for 5 to 10 days. This course may be repeated approximately every 2 weeks.


For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
2 to 3 g/m2 IV every twelve hours for up to 12 doses. The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.


For chronic granulocytic leukemia / chronic myelogenous leukemia:
20 mg/m2 subcutaneously for 10 days per month for 6 months with interferon alfa.

Usual Adult Dose for Acute Myeloid Leukemia

Acute Leukemia Induction:
100 to 200 mg/m2/day or 2 to 6 mg/kg/day as a continuous IV infusion over 24 hours or in divided doses by rapid injection for 5 to 10 days. This course may be repeated approximately every 2 weeks.


For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
2 to 3 g/m2 IV every twelve hours for up to 12 doses. The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.


For chronic granulocytic leukemia / chronic myelogenous leukemia:
20 mg/m2 subcutaneously for 10 days per month for 6 months with interferon alfa.

Usual Adult Dose for Leukemia

Acute Leukemia Induction:
100 to 200 mg/m2/day or 2 to 6 mg/kg/day as a continuous IV infusion over 24 hours or in divided doses by rapid injection for 5 to 10 days. This course may be repeated approximately every 2 weeks.


For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
2 to 3 g/m2 IV every twelve hours for up to 12 doses. The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.


For chronic granulocytic leukemia / chronic myelogenous leukemia:
20 mg/m2 subcutaneously for 10 days per month for 6 months with interferon alfa.

Usual Adult Dose for Meningeal Leukemia

The manufacturer has stated that doses ranging from 5 mg/m2 to 75 mg/m2 has been used intrathecally and the frequency of administration has varied from once a day for 4 days to once every 4 days. The manufacturer has further stated that 30 mg/m2 every 4 days until cerebrospinal fluid findings were normal, followed by one additional treatment was the therapy most frequently used.

Some clinicians today recommend 10 to 30 mg intrathecally up to 3 times a week.

Usual Pediatric Dose for Acute Nonlymphocytic Leukemia

As a part of a combination chemotherapy:
100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7) with an anthracycline.

Usual Pediatric Dose for non-Hodgkin's Lymphoma

For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
1 to 3 g/m2 IV every twelve hours for up to 12 doses The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.

Usual Pediatric Dose for Acute Myeloid Leukemia

For refractory non-Hodgkin's lymphomas and acute myeloid leukemia:
1 to 3 g/m2 IV every twelve hours for up to 12 doses The IV infusion generally takes place over 1 to 3 hours. The dose of cytarabine should be suspended or modified if the ANC is below 1000/mm3 or the platelet count is below 50,000/mm3.

Usual Pediatric Dose for Meningeal Leukemia

The manufacturer has stated that doses ranging from 5 mg/m2 to 75 mg/m2 has been used intrathecally and the frequency of administration has varied from once a day for 4 days to once every 4 days. The manufacturer has further stated that 30 mg/m2 every 4 days until cerebrospinal fluid findings were normal, followed by one additional treatment was the therapy most frequently used.

However, some clinicians recommend the following age based dosing:
<1 year: 20 mg
1 to 2 years: 30 mg
2 to 3 years: 50 mg
>3 years: 70 to 75 mg

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Any elevation in transaminases and/or bilirubin greater than 2 mg/dL: Reduce dose by 50%; may increase subsequent doses in the absence of toxicity.

Dialysis

Data not available

Other Comments

For intrathecal administration, reconstitute with preservative-free saline and use immediately.

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