Cyclophosphamide Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Malignant Disease

Intravenous: When used alone, the initial dose for patients with no hematologic deficiency is 40 to 50 mg/kg usually in divided doses over 2 to 5 days. Alternatively, 10 to 15 mg/kg may be administered every 7 to 10 days or 3 to 5 mg/kg twice a week.

Oral: Usual Range: 1 to 8 mg/kg/day for initial and maintenance dosing.

Usual Adult Dose for Ovarian Cancer

For use in the treatment of epithelial ovarian cancer:

600 mg/m2 intravenously on day one in combination with carboplatin or cisplatin
Repeat cycle every 28 days.

Usual Adult Dose for Multiple Myeloma

(In combination with other chemotherapeutic agents as a part of the M2 protocol)
10 mg/kg IV on day 1

Usual Pediatric Dose for Malignant Disease

Intravenous: When used alone, the initial dose for patients with no hematologic deficiency is 40 to 50 mg/kg usually in divided doses over 2 to 5 days. Alternatively, 10 to 15 mg/kg may be administered every 7 to 10 days or 3 to 5 mg/kg twice a week.

Oral: Usual Range: 1 to 8 mg/kg/day for initial and maintenance dosing.

Usual Pediatric Dose for Nephrotic Syndrome

When use for biopsy proven "minimal change" nephrotic syndrome in children, a dose of 2.5 to 3 mg/kg/day orally for 60 to 90 days is recommended.

Renal Dose Adjustments

Caution is recommended when used in patients with renal dysfunction. However, no specific dosage modifications are currently recommended.

Liver Dose Adjustments

Data not available

Dose Adjustments

When used in the treatment of a malignant disease, dosages must be adjusted in accordance with evidence of antitumor activity or leukopenia.

Precautions

When use for biopsy proven "minimal change" nephrotic syndrome in a male child, the incidence of oligospermia and azoospermia increases if the duration of treatment exceeds 60 days. Treatment beyond 90 days increases the probability of sterility.

Dialysis

Data not available

Other Comments

Dosages of cyclophosphamide may depend upon the specific indication for its use and whether other medications are coadministered. Reference to specific protocols is recommended.

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