Clonazepam Dosage

This dosage information may not include all the information needed to use Clonazepam safely and effectively. See additional information for Clonazepam.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Seizure Prophylaxis

Initial dose: Should not exceed 1.5 mg/day divided into three doses.

Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase.

Maintenance dose: Individualized for each patient depending upon response.

Maximum Daily Dose: 20 mg.

Usual Adult Dose for Bipolar Disorder

Initial dose: Should not exceed 1.5 mg/day divided into three doses.

Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase.

Maintenance dose: Individualized for each patient depending upon response.

Maximum Daily Dose: 20 mg.

Usual Adult Dose for Panic Disorder

Initial dose: 0.25 mg bid.

Maintenance dose: An increase to the target dose for most patients of 1 mg/day may be made after 3 days.

The dose may be increased in increments of 0.125 to 0.25 mg bid every 3 days until panic disorder is controlled or until side effects make further increases undesired. To reduce the inconvenience of somnolence, administration of one dose at bedtime may be desirable.

Maximum Dose: 4 mg/day

Treatment should be discontinued gradually, with a decrease of 0.125 mg bid every 3 days, until the drug is completely withdrawn.

Usual Pediatric Dose for Seizure Prophylaxis

<= 10 years or < 30 kg of body weight:
Initial Dose: Orally:
In order to minimize drowsiness, the initial dose should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses.

Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

>10 years and >30 kg of body weight:
The initial dose should not exceed 1.5 mg/day divided into three doses.

Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase.

The maintenance dosage should be individualized for each patient depending upon response.

Maximum Daily Dose: 20 mg.

Renal Dose Adjustments

No specific dose adjustment guidelines have been suggested; however, caution is recommended and a dosage reduction may be required.

Liver Dose Adjustments

No specific dose adjustment guidelines have been suggested; however, caution is recommended and a dosage reduction may be required.

Dose Adjustments

Slower titration and smaller maximum doses are recommended in the elderly.

Precautions

Use of clonazepam is contraindicated in patients with clinical or biochemical evidence of significant liver disease.

Use of clonazepam is also contraindicated in patients with acute narrow angle glaucoma.

Discontinuation should be performed gradually in order to minimize the risk of withdrawal symptoms.

Dialysis

Supplemental dose is not necessary with hemodialysis.

Other Comments

The largest dose should be at bedtime. The maximum recommended daily dose is 20 mg.

There is no body of evidence available to answer the question of how long the patient treated with clonazepam should remain on it. Therefore, the physician who elects to use clonazepam for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Clonazepam is available as a tablet or an orally disintegrating tablet (wafer). The tablets should be administered with water by swallowing the tablet whole. The orally disintegrating tablet should be administered as follows: After opening the pouch, peel back the foil on the blister. Do not push tablet through foil. Immediately upon opening the blister, using dry hands, remove the tablet and place it in the mouth. Tablet disintegration occurs rapidly in saliva so it can be easily swallowed with or without water.

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