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Clomipramine Dosage

Applies to the following strength(s): 25 mg ; 50 mg ; 75 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Obsessive Compulsive Disorder

Initial dose: 25 mg orally once a day at bedtime
Maintenance dose: 100 mg orally per day
Maximum dose: 250 mg per day

Comments:
-The dose should be increased gradually, as tolerated, to 100 mg during the first 2 weeks. After the initial titration, the dose may be increased gradually over the next several weeks, up to a maximum of 250 mg per day.
-During initial titration, this drug should be given in divided doses with meals to reduce gastrointestinal side effects.
-During maintenance, the total daily dose may be given once a day at bedtime to minimize daytime sedation.
-Dosage adjustments should be made to maintain the patient on the lowest effective dosage.

Use: Treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD)

Usual Pediatric Dose for Obsessive Compulsive Disorder

10 to 17 years:
Initial dose: 25 mg orally once a day at bedtime
Maintenance dose: May increase to 3 mg/kg or 100 mg orally per day, whichever is the smaller dose
Maximum dose: 3 mg/kg/day or 200 mg orally per day, whichever is the smaller dose

Comments:
-During initial titration, this drug should be given in divided doses with meals to reduce gastrointestinal side effects.
-After titration, the total daily dose may be given once a day at bedtime to minimize daytime sedation.
-Dosage adjustments should be made to maintain the patient on the lowest effective dosage.

Use: Treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

BOXED WARNING(S):
Suicidality and Antidepressant Drugs
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
-Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients except for patients with obsessive compulsive disorder (OCD)

Safety and effectiveness in the pediatric population other than pediatric patients with OCD have not been established.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:
-Protect from moisture

Monitoring:
-Psychiatric: Patients should be monitored for worsening and emergence of suicidal thoughts.

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