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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Ovulation Induction
50 mg orally once a day for 5 days. Therapy should be initiated on or near the 5th day of the menstrual cycle, but may be started at any time in patients without recent uterine bleeding.
If ovulation occurs and pregnancy is not achieved, up to 2 additional courses of clomiphene 50 mg orally once a day for 5 days may be administered. Each subsequent course may be started as early as 30 days after the previous course and after pregnancy has been excluded.
Most patients ovulate following the first course of therapy. However, if the patient fails to ovulate, a second course of 100 mg/day for 5 days may be given as early as 30 days following the initial course. A third course of 100 mg/day for 5 days may be given after 30 days, if necessary.
Treatments beyond three cycles of clomiphene, dosages greater than 100 mg once a day, and/or course durations beyond 5 days are not recommended by the manufacturer. However, successful pregnancies and term deliveries have been reported in women receiving up to 200 mg/day for 5 days, or extended 10-day course of therapy, or consecutive cycles of treatment beyond the 3 recommended by the manufacturer.
Usual Adult Dose for Lactation Suppression
50 to 100 mg orally once a day for 5 days. Generally, one course of therapy is sufficient.
Usual Adult Dose for Oligospermia
25 to 100 mg orally once a day. Therapy is generally given over a period of several months.
Renal Dose Adjustments
Dosage reductions are not recommended for patients with renal dysfunction during short term clomiphene therapy. Dosage reductions are also not recommended for patients with renal dysfunction during long term clomiphene therapy. However, the half-life of clomiphene may be prolonged with chronic therapy and patients with renal dysfunction should be monitored for patient response and tolerance.
Liver Dose Adjustments
Clomiphene is contraindicated in patients with liver disease or a history of liver dysfunction.
Data not available