Chlorothiazide / Reserpine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1-2 tablets (chlorothiazide/reserpine 250 mg-0.125 mg) orally once or twice a day or
1 tablet (chlorothiazide/reserpine 500 mg-0.125 mg) orally once or twice a day.
Should conform to the dosages of the individual components established during titration.

Renal Dose Adjustments

Chlorothiazide is not recommended in patients with severe renal insufficiency since it is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 25 mL/min.

The elimination half-life of reserpine may be significantly increased in patients with renal insufficiency, therefore reserpine is not recommended in patients with renal dysfunction.

Liver Dose Adjustments

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Dose Adjustments

Dosage may require adjustment according to the blood pressure response of the patient. For maintenance, the dosage should be adjusted to the lowest requirement of the individual patient.

Precautions

Doses higher than 0.25 mg daily of reserpine should be used cautiously, because occurrence of serious mental depression and other side effects may increase considerably.
Use chlorothiazide with caution in severe renal disease and/or impaired hepatic function.

Dialysis

Reserpine is not dialyzable. The degree to which chlorothiazide is removed by hemodialysis has not been established.

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