Cephradine Dosage

Usual Adult Dose for Cystitis

Uncomplicated: 500 mg orally every 12 hours
Complicated: 500 mg orally every 6 hours or 1 g orally every 12 hours

Usual Adult Dose for Otitis Media

250 mg orally every 6 hours or 500 mg orally every 12 hours

Usual Adult Dose for Pharyngitis

250 mg orally every 6 hours or 500 mg orally every 12 hours

Usual Adult Dose for Upper Respiratory Tract Infection

250 mg orally every 6 hours or 500 mg orally every 12 hours

Usual Adult Dose for Pyelonephritis

500 mg to 1 g orally every 6 hours
Therapy should be continued for approximately 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection

250 mg orally every 6 hours or 500 mg orally every 12 hours

Usual Pediatric Dose for Pharyngitis

9 months or older: 25 to 50 mg/kg/day in divided doses every 6 to 12 hours
Maximum dose: 4 g per day

Usual Pediatric Dose for Upper Respiratory Tract Infection

9 months or older: 25 to 50 mg/kg/day in divided doses every 6 to 12 hours
Maximum dose: 4 g per day

Usual Pediatric Dose for Bacterial Infection

9 months or older: 25 to 50 mg/kg/day in divided doses every 6 to 12 hours
Maximum dose: 4 g per day

Usual Pediatric Dose for Skin and Structure Infection

9 months or older: 25 to 50 mg/kg/day in divided doses every 6 to 12 hours
Maximum dose: 4 g per day

Usual Pediatric Dose for Otitis Media

9 months or older: 75 to 100 mg/kg/day in divided doses every 6 to 12 hours
Maximum dose: 4 g per day

Renal Dose Adjustments

CrCl 21 mL/min or more: 500 mg orally every 6 hours
CrCl 5 to 20 mL/min: 250 mg orally every 6 hours
CrCl 4 mL/min or less: 250 mg orally every 12 hours

Liver Dose Adjustments

Data not available.

Dose Adjustments

Severe or chronic infections may require doses up to 1 g orally every 6 hours or up to 8 g/day intramuscularly.

Precautions

Clostridium difficile associated diarrhea (CDAD) has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following cephalosporin therapy. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.

Cephalosporins may be associated with a fall in prothrombin activity. Risk factors include renal or hepatic impairment, poor nutritional state, a protracted course of antimicrobial therapy, and chronic anticoagulation therapy. Prothrombin times should be monitored and vitamin K therapy initiated if indicated.

Serious and occasionally fatal hypersensitivity reactions have been reported with antibiotics. The drug should be discontinued immediately at the first appearance of a skin rash or other signs of hypersensitivity. Severe, acute hypersensitivity reactions may require treatment with epinephrine and other resuscitative measures including oxygen, intravenous fluids, antihistamines, corticosteroids, cardiovascular support and airway management as clinically indicated.

Dosage adjustments are recommended in patients with impaired renal function (CrCl 20 mL/min or less or on hemodialysis). Some cephalosporins have been associated with seizures in renally impaired patients with elevated serum concentrations. The drug should be discontinued if seizures occur. Nephrotoxicity has occurred with concomitant cephalosporins and aminoglycosides or potent diuretics. Renal function should be monitored, especially in elderly patients.

Dialysis

Patients on chronic intermittent hemodialysis should receive 250 mg initially, repeated at 12 hours and after 36 to 48 hours.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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