Carboprost Dosage

This dosage information may not include all the information needed to use Carboprost safely and effectively. See additional information for Carboprost.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Abortion

Initial dose: 250 mcg (1 mL) intramuscularly once. The dose should be administered deep into the muscle with a tuberculin syringe.

Subsequent doses of 250 mcg (1 mL) may be administered at 1.5 to 3.5 hour intervals depending on uterine response.

An optional test dose of 100 mcg (0.4 mL) may be administered initially. The dose may be increased to 500 mcg (2 mL) if uterine contractility is judged to be inadequate after several doses of 250 mcg (1 mL).

The total dose of carboprost administered should not exceed 12 milligrams and continuous administration of the drug for more than 2 days is not recommended.

Abortion induced by carboprost may be expected to be incomplete in about 20% of cases (the same percentage as with spontaneous abortions).

While the incidence of cervical trauma is extremely small, the cervix should always be examined immediately postabortion.

Usual Adult Dose for Postpartum Bleeding

Initial dose: 250 mcg (1 mL) administered deeply intramuscularly once.

Clinical trials have reported that 73% of cases responded to single injections.

In some selected cases, multiple dosing at intervals of 15 to 90 minutes was reported to have had a successful outcome.

The need for additional injections and the interval at which additional injections should be administered must be determined by the attending physician as dictated by the course of clinical events.

The total dose of carboprost should not exceed 2 mg (8 doses or 8 mL).

Renal Dose Adjustments

Carboprost is contraindicated for use in the treatment of patients with active renal disease.

Liver Dose Adjustments

Carboprost is contraindicated for use in the treatment of patients with active hepatic disease.

Precautions

Carboprost is contraindicated for use in the treatment of patients with pelvic inflammatory disease. Carboprost is also contraindicated for use in the treatment of patients with active cardiac or pulmonary disease.

Carboprost should be administered with strict adherence to recommended dosages.

Dialysis

Carboprost is contraindicated for use in the treatment of patients with active renal disease.

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