Capastat Dosage

Generic name: capreomycin sulfate
Dosage form: injection, powder, for solution

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Capastat Sulfate may be administered intramuscularly or intravenously following reconstitution. Reconstitution is achieved by dissolving the vial contents (1 g) in 2 mL of 0.9% Sodium Chloride Injection or Sterile Water for Injection. Two to 3 minutes should be allowed for complete dissolution.

Intravenously— For intravenous infusion, reconstituted Capastat Sulfate should be diluted in 100 mL of 0.9% Sodium Chloride Injection and administered over 60 minutes.

Intramuscularly— Reconstituted Capastat Sulfate should be given by deep intramuscular injection into a large muscle mass, since superficial injection may be associated with increased pain and the development of sterile abscesses.

For administration of a 1–g dose, the entire contents of the vial should be given. For doses lower than 1 g, the following dilution table may be used.

DILUTION TABLE
*
Equivalent to capreomycin activity. Approximated concentration takes into account the retention volume.

Diluent Added to
1-g, 10-mL Vial

Volume of Capastat
Sulfate Solution

Concentration
(Approx)

 2.15 mL

  2.85 mL

370 mg*/mL

 2.63 mL

  3.33 mL

315 mg*/mL

3.3 mL

4 mL

260 mg*/mL

4.3 mL

5 mL

210 mg*/mL

The solution may acquire a pale straw color and darken with time, but this is not associated with loss of potency or the development of toxicity. After reconstitution, all solutions of Capastat Sulfate may be stored for up to 24 hours under refrigeration.

Capreomycin is always administered in combination with at least 1 other antituberculosis agent to which the patient’s strain of tubercle bacilli is susceptible. The usual dose is 1 g daily (not to exceed 20 mg/kg/day) given intramuscularly or intravenously for 60 to 120 days, followed by 1 g by either route 2 or 3 times weekly. (Note — Therapy for tuberculosis should be maintained for 12 to 24 months. If facilities for administering injectable medication are not available, a change to appropriate oral therapy is indicated on the patient’s release from the hospital.)

Patients with reduced renal function should have dosage reduction based on creatinine clearance using the guidelines included in Table 1. These dosages are designed to achieve a mean steady–state capreomycin level of 10 μg/mL.

Table 1. Estimated Dosages to Attain Mean Steady-State Serum Capreomycin Concentration of 10 µg/mL (Based on Creatinine Clearance)
*
For patients with renal impairment, initial maintenance dose estimates are given for optional dosing intervals; longer dosing intervals are expected to provide greater peak and lower trough serum capreomycin levels than shorter dosing intervals.
The usual dosage for patients with normal renal function is 1000 mg daily, not to exceed 20 mg/kg/day, for 60 to 120 days, then 1000 mg 2 to 3 times weekly.

Capreomycin

Dose* (mg/kg) for the Following

CrCl

Clearance

Half-life

Dosing Intervals

(mL/min)

(L/kg/h x 10 –2)

(hours)

24 h

48 h

72 h

0

0.54

55.5

  1.29

  2.58

  3.87

10

1.01

29.4

  2.43

  4.87

  7.30

20

1.49

20.0

  3.58

  7.16

10.7

30

1.97

15.1

  4.72

  9.45

14.2

40

2.45

12.2

  5.87

11.7

50

2.92

10.2

  7.01

14.0

60

3.40

  8.8

  8.16

80

4.35

  6.8

10.4

100

5.31

  5.6

12.7

110

5.78

  5.2

13.9

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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