Candesartan Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 16 mg orally once a day.
Maintenance dose: Daily ranges of 8 to 32 mg administered once or twice daily.

Usual Adult Dose for Congestive Heart Failure

Initial dose: 4 mg orally once daily. The target dose is 32 mg once daily, achieved by doubling the dose at approximately two week intervals, as tolerated by the patient.

Usual Pediatric Dose for Hypertension

All doses may be administered once daily or divided into 2 equal doses:

1 to less than 6 years of age:
Initial dose: 0.20 mg/kg (oral suspension)
Maintenance dose: 0.05 to 0.4 mg/kg orally daily

6 to less than 17 years of age:
Less than 50 kg:
Initial dose: 4 to 8 mg orally daily
Maintenance dose: 2 to 16 mg orally daily
Greater than 50 kg:
Initial dose: 8 to 16 mg orally daily
Maintenance dose: 4 to 32 mg orally daily

Doses above 0.4 mg/kg (1 to less than 6 year olds) or 32 mg (6 to less than 17 year olds) have not been studied in pediatric patients.

Renal Dose Adjustments

No initial dose adjustment is required for patients with mildly impaired renal function.

Consideration should be given to initiation of candesartan at a lower dose in patients with moderate to severe renal impairment.

Candesartan has not been studied in children with estimated glomerular filtration rate less than 30 mL/min/1.73 m2.

Liver Dose Adjustments

No initial dose adjustment is required for patients with mildly impaired hepatic function.

Consideration should be given to initiation of candesartan at a lower dose in patients with moderate to severe hepatic impairment.

Dose Adjustments

In patients with possible intravascular volume depletion, candesartan should be administered with caution and a lower dose should be considered.

No initial dose adjustment is recommended in geriatric patients.

Precautions

Caution is advised when treating older individuals as increased sensitivity to candesartan therapy should be considered.

Doses above 0.4 mg/kg (1 to less than 6 year olds) or 32 mg (6 to less than 17 year olds) have not been studied in pediatric patients.

Safety and effectiveness have not been established in pediatric patients less than 1 year old.

Dialysis

Candesartan is not removed by hemodialysis. An increased risk of hypotension exists if the dose is given immediately following dialysis. Ideally, the drug should be given when the patient is hemodynamically stable.

Other Comments

If blood pressure is not controlled by candesartan alone, a diuretic may be added.

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

Hide
(web2)