Canakinumab Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cryopyrin-Associated Periodic Syndrome

Body weight greater than 40 kg
Recommended dose: 150 mg as a single dose via subcutaneous injection

Body weight between 15 kg and 40 kg
Recommended dose: 2 mg/kg as a single dose via subcutaneous injection

Canakinumab is administered every eight weeks.

Usual Pediatric Dose for Cryopyrin-Associated Periodic Syndrome

Body weight greater than 40 kg
Recommended dose: 150 mg as a single dose via subcutaneous injection

Body weight between 15 kg and 40 kg
Recommended dose: 2 mg/kg as a single dose via subcutaneous injection

For children 15 to 40 kg with an inadequate response, the dose can be increased to 3 mg/kg as a single dose via subcutaneous injection.

Canakinumab is administered every eight weeks.

Usual Pediatric Dose for Juvenile Idiopathic Arthritis

4 mg/kg subcutaneously every four weeks

Maximum dose: 300 mg

Comments: Approved dosing is only for body weight greater than 7.5 kg.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Clinical studies of canakinumab did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

Dialysis

Data not available

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