Applies to the following strength(s): 5 mg ; 10 mg ; 15 mg ; 30 mg ; 7.5 mg
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Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Anxiety
Initial dose: 7.5 mg orally two times a day or 5 mg 3 times a day.
Maintenance dose: The daily dose may be increased in 5 mg increments every 2 to 3 days up to 20 to 60 mg/day in divided doses.
Maximum dose: 60 mg per day
Usual Pediatric Dose for Anxiety
6 to 18 years:
Initial dose: 2.5 to 10 mg daily.
Maintenance dose: The daily dose may be increased in 2.5 mg increments every 2 to 3 days to 15 to 60 mg/day given in 2 divided doses.
Study (n=26) Anxiety and Moderately Severe Aggression:
5 to 15 years: 5 mg daily, titrated upwards every 3 days by 5 to 10 mg, to a maximum of 50 mg daily dose.
Study (n=22) Anxiety and Irritability in Children with Pervasive Developmental Disorders:
6 to 17 years: 5 mg three times daily, titrated to a maximum of 45 mg/day within 3 weeks.
Renal Dose Adjustments
Use is not recommended in patients with severe renal impairment.
Liver Dose Adjustments
Use is not recommended in patients with severe hepatic impairment.
Dose reductions are recommended when given concurrently with erythromycin (e.g., 2.5 mg twice daily) and itraconazole (e.g., 2.5 mg daily) and adjustments should be based on the patient's clinical response. Reduced dosages may also be necessary when given with other CYP450 3A4 inhibitors.
The concurrent use of buspirone and an MAO inhibitor is not recommended.
Dialyzability has not been determined and use is not recommended in patients with severe renal impairment.
The maximum daily dosage should not exceed 60 mg.