Buspirone Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anxiety

Initial dose: 7.5 mg orally two times a day or 5 mg 3 times a day.
Maintenance dose: The daily dose may be increased in 5 mg increments every 2 to 3 days up to 20 to 60 mg/day in divided doses.
Maximum dose: 60 mg per day

Usual Pediatric Dose for Anxiety

6 to 18 years:
Initial dose: 2.5 to 10 mg daily.
Maintenance dose: The daily dose may be increased in 2.5 mg increments every 2 to 3 days to 15 to 60 mg/day given in 2 divided doses.

Study (n=26) Anxiety and Moderately Severe Aggression:
5 to 15 years: 5 mg daily, titrated upwards every 3 days by 5 to 10 mg, to a maximum of 50 mg daily dose.

Study (n=22) Anxiety and Irritability in Children with Pervasive Developmental Disorders:
6 to 17 years: 5 mg three times daily, titrated to a maximum of 45 mg/day within 3 weeks.

Renal Dose Adjustments

Use is not recommended in patients with severe renal impairment.

Liver Dose Adjustments

Use is not recommended in patients with severe hepatic impairment.

Dose Adjustments

Dose reductions are recommended when given concurrently with erythromycin (e.g., 2.5 mg twice daily) and itraconazole (e.g., 2.5 mg daily) and adjustments should be based on the patient's clinical response. Reduced dosages may also be necessary when given with other CYP450 3A4 inhibitors.

Precautions

The concurrent use of buspirone and an MAO inhibitor is not recommended.

Dialysis

Dialyzability has not been determined and use is not recommended in patients with severe renal impairment.

Other Comments

The maximum daily dosage should not exceed 60 mg.

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