Botulism Immune Globulin Dosage

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Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Botulism

Less than one year of age with infant botulism caused by toxin type A or B:

2 mL/kg (100 mg/kg), given as a single intravenous infusion as soon as the clinical diagnosis of infant botulism is made. Add 2 mL sterile water for injection to the 100 mg vial, resulting in 50 mg/mL solution. Infusion should begin within 2 hours after reconstitution is complete and should be concluded within 4 hours of reconstitution. The infusion should begin slowly. Administration should start at 0.5 mL per kg body weight per hr (25 mg/kg/hr). If no untoward reactions occur after 15 minutes, the rate may be increased to the maximum infusion rate of 1 mL/kg/hr (50 mg/kg/hr). At the recommended rates, infusion of the indicated dose should take 127.5 minutes total elapsed time.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Do not exceed the recommended dose, concentration, and rate of infusion.

Dialysis

Data not available

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