This dosage information may not include all the information needed to use Bevacizumab safely and effectively. See additional information for Bevacizumab.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
- Colorectal Cancer
- Non-Small Cell Lung Cancer
- Breast Cancer
- Glioblastoma Multiforme
- Ovarian Cancer
- Renal Cell Carcinoma
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Colorectal Cancer
5 mg/kg IV every 2 weeks when used in combination with irinotecan, fluorouracil, and leucovorin in the IFL regimen.
10 mg/kg IV every 2 weeks when used in combination with oxaliplatin, folinic acid, and fluorouracil in the FOLFOX4 regimen.
Administer 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks when used in combination with a fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy regimen in patients who have progressed on a first-line bevacizumab containing regimen.
Duration of therapy: Continue treatment until disease progression or unacceptable toxicity occurs.
Comments: The first dose of bevacizumab should be delivered over 90 minutes as an IV infusion following chemotherapy. If the first infusion is well tolerated, the second infusion may be administered over 60 minutes. If the 60 minute infusion is well tolerated, all subsequent infusions may be administered over 30 minutes, if tolerated.
Usual Adult Dose for Non-Small Cell Lung Cancer
For use in combination with carboplatin and paclitaxel for the treatment of non-squamous, non-small cell lung cancer:
Initial dose: 15 mg/kg as an IV infusion every 3 weeks
The first dose of bevacizumab should be delivered over 90 minutes as an IV infusion following chemotherapy. If the first infusion is well tolerated, the second infusion may be administered over 60 minutes. If the 60 minute infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.
Usual Adult Dose for Breast Cancer
(Not approved by FDA)
Recommended dose: 10 mg/kg as an IV infusion every 14 days in combination with paclitaxel.
Usual Adult Dose for Glioblastoma Multiforme
Recommended dose: 10 mg/kg every 2 weeks
Usual Adult Dose for Ovarian Cancer
15 mg/kg IV every 3 weeks
Usual Adult Dose for Renal Cell Carcinoma
10 mg/kg IV every 2 weeks in combination with interferon alfa
Usual Pediatric Dose for Solid Tumors
Monotherapy: 15 mg/kg IV every 2 weeks in 28 day cycles
Combination therapy: 5 to 10 mg/kg IV every 2 weeks as a part of combination chemotherapy regimens
Renal Dose Adjustments
Data Not Available
Liver Dose Adjustments
Data Not Available
There are no recommended dose reductions for the use of bevacizumab. If needed, bevacizumab should be either discontinued or temporarily suspended.
Do not give as an IV bolus injection.
Bevacizumab should be permanently discontinued in patients who develop gastrointestinal perforation, wound dehiscence requiring medical intervention, serious bleeding, nephrotic syndrome, or hypertensive crisis.
Temporary suspension of bevacizumab is recommended in patients with evidence of moderate to severe proteinuria pending further evaluation and in patients with severe hypertension that is not controlled with medical management. The risk of continuation or temporary suspension of bevacizumab in patients with moderate to severe proteinuria is unknown.
Data Not Available
Bevacizumab therapy should not be initiated for at least 28 days following major surgery. If the patient has had surgery, the surgical incision should be fully healed prior to initiation of bevacizumab.
More about bevacizumab
- Other brands: Avastin