Bevacizumab Dosage

This dosage information may not include all the information needed to use Bevacizumab safely and effectively. See additional information for Bevacizumab.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Colorectal Cancer

5 mg/kg IV every 2 weeks when used in combination with irinotecan, fluorouracil, and leucovorin in the IFL regimen.

10 mg/kg IV every 2 weeks when used in combination with oxaliplatin, folinic acid, and fluorouracil in the FOLFOX4 regimen.

Administer 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks when used in combination with a fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy regimen in patients who have progressed on a first-line bevacizumab containing regimen.

Duration of therapy: Continue treatment until disease progression or unacceptable toxicity occurs.

Comments: The first dose of bevacizumab should be delivered over 90 minutes as an IV infusion following chemotherapy. If the first infusion is well tolerated, the second infusion may be administered over 60 minutes. If the 60 minute infusion is well tolerated, all subsequent infusions may be administered over 30 minutes, if tolerated.

Usual Adult Dose for Non-Small Cell Lung Cancer

For use in combination with carboplatin and paclitaxel for the treatment of non-squamous, non-small cell lung cancer:

Initial dose: 15 mg/kg as an IV infusion every 3 weeks

The first dose of bevacizumab should be delivered over 90 minutes as an IV infusion following chemotherapy. If the first infusion is well tolerated, the second infusion may be administered over 60 minutes. If the 60 minute infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.

Usual Adult Dose for Breast Cancer

(Not approved by FDA)

Recommended dose: 10 mg/kg as an IV infusion every 14 days in combination with paclitaxel.

Usual Adult Dose for Glioblastoma Multiforme

Recommended dose: 10 mg/kg every 2 weeks

Usual Adult Dose for Ovarian Cancer

15 mg/kg IV every 3 weeks

Usual Adult Dose for Renal Cell Carcinoma

10 mg/kg IV every 2 weeks in combination with interferon alfa

Usual Pediatric Dose for Solid Tumors

Monotherapy: 15 mg/kg IV every 2 weeks in 28 day cycles

Combination therapy: 5 to 10 mg/kg IV every 2 weeks as a part of combination chemotherapy regimens

Renal Dose Adjustments

Data Not Available

Liver Dose Adjustments

Data Not Available

Dose Adjustments

There are no recommended dose reductions for the use of bevacizumab. If needed, bevacizumab should be either discontinued or temporarily suspended.

Precautions

Do not give as an IV bolus injection.

Bevacizumab should be permanently discontinued in patients who develop gastrointestinal perforation, wound dehiscence requiring medical intervention, serious bleeding, nephrotic syndrome, or hypertensive crisis.

Temporary suspension of bevacizumab is recommended in patients with evidence of moderate to severe proteinuria pending further evaluation and in patients with severe hypertension that is not controlled with medical management. The risk of continuation or temporary suspension of bevacizumab in patients with moderate to severe proteinuria is unknown.

Dialysis

Data Not Available

Other Comments

Bevacizumab therapy should not be initiated for at least 28 days following major surgery. If the patient has had surgery, the surgical incision should be fully healed prior to initiation of bevacizumab.

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