Auranofin Dosage
This dosage information may not include all the information needed to use Auranofin safely and effectively. See additional information for Auranofin.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Rheumatoid Arthritis
Initial: 3 mg orally once a day for 2 weeks. The goal of therapy is to gradually taper up to a dose of 6 mg orally each day with limited diarrhea.
Maintenance: 6 mg orally each day administered either as a single dose or as 3 mg orally twice a day to decrease the incidence of gastrointestinal side effects.
A therapeutic response to auranofin may not be clinically apparent for 3 to 6 months after initiation of therapy. If, after this time, the response is considered inadequate the dosage may be increased to a maximum of 3 mg orally 3 times a day. If the response remains inadequate after 2 to 3 months at 9 mg/day, an alternative therapy should be considered.
Usual Pediatric Dose for Rheumatoid Arthritis
>1 to 12 years:
Initial: 0.1 mg/kg/day in 1 to 2 equally divided doses.
>1 to 12 years:
Maintenance: 0.15 mg/kg/day in 1 to 2 equally divided doses, with a maximum dose of 0.2 mg/kg/day administered in a single dose or equally divided doses 12 hours apart.
Renal Dose Adjustments
CrCl < 50 mL/min: auranofin is contraindicated for use in these patients.
CrCl 50 to 80 mL/min: the dose should be reduced by 50%.
Dose Adjustments
To reduce the risk of diarrhea, a 3 mg dose given once a day for the first 2 weeks is recommended. The dose can be increased to 3 mg orally 3 times a day if after 6 months the response is inadequate.
Other Comments
The maximum dose is 9 mg/day. A therapeutic response may not be seen for 3-6 months.
