Atropine / Pralidoxime Dosage

This dosage information may not include all the information needed to use Atropine / Pralidoxime safely and effectively. See additional information for Atropine / Pralidoxime.

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Organophosphate Poisoning

TREATMENT OF MILD SYMPTOMS
Mild symptoms include blurred vision, miosis, excessive, unexplained runny nose, increased salivation such as sudden drooling, chest tightness or difficulty breathing, tremors throughout the body or muscular twitching, nausea and/or vomiting, unexplained wheezing, coughing or increased airway secretions, acute onset of stomach cramps, and tachycardia or bradycardia.

First dose: In the situation of known or suspected organophosphorous poisoning, administer one (1) atropine-pralidoxime 2.1 mm/0.7 mL-600 mg/ 2 mL injection (DuoDote auto-injector) into the midlateral thigh if the patient experiences two or more MILD symptoms of nerve gas or insecticide exposure. Emergency medical services personnel with mild symptoms may self-administer a single dose of atropine-pralidoxime (DuoDote).

Wait 10 to 15 minutes for atropine-pralidoxime (DuoDote) to take effect. If, after 10 to 15 minutes, the patient does not develop any SEVERE symptoms (strange or confused behavior, severe difficulty breathing or copious secretions from lungs/airway, severe muscular twitching and general weakness, involuntary urination and defecation, convulsions or unconsciousness), no additional atropine-pralidoxime (DuoDote) injections are recommended, but definitive medical care should ordinarily be sought immediately. For emergency medical services personnel who have self-administered atropine-pralidoxime (DuoDote), an individual decision will need to be made to determine their capacity to continue to provide emergency care.

Additional doses: If, at any time after the first dose, the patient develops any of the SEVERE symptoms listed above, administer two (2) additional atropine-pralidoxime (DuoDote) injections in rapid succession, and immediately seek definitive medical care.

TREATMENT OF SEVERE SYMPTOMS
Severe symptoms include strange or confused behavior, severe difficulty breathing or copious secretions from lungs/airway, severe muscular twitching and general weakness, involuntary urination and defecation, convulsions or unconsciousness.

Immediately administer three (3) atropine-pralidoxime (DuoDote) injections into the patient's midlateral thigh in rapid succession, and immediately seek definitive medical care.

Usual Adult Dose for Nerve Agent Poisoning

TREATMENT OF MILD SYMPTOMS
Mild symptoms include blurred vision, miosis, excessive, unexplained runny nose, increased salivation such as sudden drooling, chest tightness or difficulty breathing, tremors throughout the body or muscular twitching, nausea and/or vomiting, unexplained wheezing, coughing or increased airway secretions, acute onset of stomach cramps, and tachycardia or bradycardia.

First dose: In the situation of known or suspected organophosphorous poisoning, administer one (1) atropine-pralidoxime 2.1 mm/0.7 mL-600 mg/ 2 mL injection (DuoDote auto-injector) into the midlateral thigh if the patient experiences two or more MILD symptoms of nerve gas or insecticide exposure. Emergency medical services personnel with mild symptoms may self-administer a single dose of atropine-pralidoxime (DuoDote).

Wait 10 to 15 minutes for atropine-pralidoxime (DuoDote) to take effect. If, after 10 to 15 minutes, the patient does not develop any SEVERE symptoms (strange or confused behavior, severe difficulty breathing or copious secretions from lungs/airway, severe muscular twitching and general weakness, involuntary urination and defecation, convulsions or unconsciousness), no additional atropine-pralidoxime (DuoDote) injections are recommended, but definitive medical care should ordinarily be sought immediately. For emergency medical services personnel who have self-administered atropine-pralidoxime (DuoDote), an individual decision will need to be made to determine their capacity to continue to provide emergency care.

Additional doses: If, at any time after the first dose, the patient develops any of the SEVERE symptoms listed above, administer two (2) additional atropine-pralidoxime (DuoDote) injections in rapid succession, and immediately seek definitive medical care.

TREATMENT OF SEVERE SYMPTOMS
Severe symptoms include strange or confused behavior, severe difficulty breathing or copious secretions from lungs/airway, severe muscular twitching and general weakness, involuntary urination and defecation, convulsions or unconsciousness.

Immediately administer three (3) atropine-pralidoxime (DuoDote) injections into the patient's midlateral thigh in rapid succession, and immediately seek definitive medical care.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

No more than three doses of atropine-pralidoxime (DuoDote) should be administered unless definitive medical care (e.g., hospitalization, respiratory support) is available.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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