Atropine / Hyoscyamine / Phenobarbital / Scopolamine Dosage

This dosage information may not include all the information needed to use Atropine / Hyoscyamine / Phenobarbital / Scopolamine safely and effectively. See additional information for Atropine / Hyoscyamine / Phenobarbital / Scopolamine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Duodenal Ulcer

Regular release tablets: 1 to 2 tablets orally 3 to 4 times a day according to condition and severity of symptoms
Elixir: 5 to 10 mL orally 3 to 4 times a day according to condition and severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours; if necessary, 1 tablet orally every 8 hours may be given

Usual Adult Dose for Irritable Bowel Syndrome

Regular release tablets: 1 to 2 tablets orally 3 to 4 times a day according to condition and severity of symptoms
Elixir: 5 to 10 mL orally 3 to 4 times a day according to condition and severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours; if necessary, 1 tablet orally every 8 hours may be given

Usual Adult Dose for Enterocolitis

Regular release tablets: 1 to 2 tablets orally 3 to 4 times a day according to condition and severity of symptoms
Elixir: 5 to 10 mL orally 3 to 4 times a day according to condition and severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours; if necessary, 1 tablet orally every 8 hours may be given

Usual Pediatric Dose for Duodenal Ulcer

Elixir:
Initial dose:
4.5 kg to less than 9.1 kg: 0.5 mL orally every 4 hours or 0.75 mL orally every 6 hours
9.1 kg to less than 13.6 kg: 1 mL orally every 4 hours or 1.5 mL orally every 6 hours
13.6 kg to less than 22.7 kg: 1.5 mL orally every 4 hours or 2 mL orally every 6 hours
22.7 kg to less than 34 kg: 2.5 mL orally every 4 hours or 3.75 mL orally every 6 hours
34 kg to less than 45.4 kg: 3.75 mL orally every 4 hours or 1 mL orally every 6 hours
45.4 kg or greater: 5 mL orally every 4 hours or 7.5 mL orally every 6 hours

Usual Pediatric Dose for Irritable Bowel Syndrome

Elixir:
Initial dose:
4.5 kg to less than 9.1 kg: 0.5 mL orally every 4 hours or 0.75 mL orally every 6 hours
9.1 kg to less than 13.6 kg: 1 mL orally every 4 hours or 1.5 mL orally every 6 hours
13.6 kg to less than 22.7 kg: 1.5 mL orally every 4 hours or 2 mL orally every 6 hours
22.7 kg to less than 34 kg: 2.5 mL orally every 4 hours or 3.75 mL orally every 6 hours
34 kg to less than 45.4 kg: 3.75 mL orally every 4 hours or 1 mL orally every 6 hours
45.4 kg or greater: 5 mL orally every 4 hours or 7.5 mL orally every 6 hours

Usual Pediatric Dose for Enterocolitis

Elixir:
Initial dose:
4.5 kg to less than 9.1 kg: 0.5 mL orally every 4 hours or 0.75 mL orally every 6 hours
9.1 kg to less than 13.6 kg: 1 mL orally every 4 hours or 1.5 mL orally every 6 hours
13.6 kg to less than 22.7 kg: 1.5 mL orally every 4 hours or 2 mL orally every 6 hours
22.7 kg to less than 34 kg: 2.5 mL orally every 4 hours or 3.75 mL orally every 6 hours
34 kg to less than 45.4 kg: 3.75 mL orally every 4 hours or 1 mL orally every 6 hours
45.4 kg or greater: 5 mL orally every 4 hours or 7.5 mL orally every 6 hours

Renal Dose Adjustments

The manufacturer recommends caution when administering this drug to patients with renal disease.

Liver Dose Adjustments

The manufacturer recommends caution when administering this drug to patients with liver disease.

Phenobarbital is metabolized by the liver and should be used with caution in patients with hepatic dysfunction. Initial doses should be small in patients with hepatic dysfunction.

Precautions

The phenobarbital component may be habit forming and should not be administered to individuals known to be addiction prone or to those with a history of physical and/or psychological dependence upon drugs.

Phenobarbital may decrease the effect of anticoagulants, and necessitate larger dosages of the anticoagulant for optimal effect. When phenobarbital is discontinued the dosage of anticoagulant may have to be decreased.

Because belladonna alkaloids are highly anticholinergic drugs, atropine/hyoscyamine/phenobarbital/scopolamine meets Beers criteria as a medication that is potentially inappropriate for use in older adults.

Dialysis

Data not available

Other Comments

Atropine/hyoscyamine/phenobarbital/scopolamine has been classified as "possibly" effective by the FDA for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.

It has not been shown conclusively whether anticholinergic/antispasmodic drugs aid in the healing of duodenal ulcer, decrease the rate of recurrences, or prevent complications.

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