Generic name: atropine and pralidoxime chloride
Dosage form: injection
This dosage information does not include all the information needed to use ATNAA safely and effectively. See full prescribing information for ATNAA.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
For optimal reactivation of organophosphorous-inhibited cholinesterase, the ATNAA should be administered as soon as possible after appearance of symptoms of nerve agent poisoning (see below).
The ATNAA should be self- or buddy-administered by military personnel after donning protective mask and hood at the first sign of a chemical attack, and only if some or all of the following mild symptoms of nerve agent exposure are present:
- Unexplained runny nose
- Unexplained sudden headache
- Sudden drooling
- Difficulty in seeing (dimness of vision and miosis)
- Tightness of chest or difficulty in breathing
- Wheezing and coughing
- Localized sweating and muscular twitching in the area of contaminated skin
- Stomach cramps
- Nausea, with or without vomiting
- Tachycardia followed by bradycardia
The following are the instructions that should be given to military personnel.
- Administer one (1) ATNAA into your lateral thigh muscle or buttocks as follows:
- Remove gray safety cap from back end.
- Place front end on outer thigh and push hard until injector functions.
Hold firmly in place for ten seconds.
- Using a hard surface, bend needle into hook. Push ejected needle through a pocket flap (or other thick and conspicuous part of outer clothing).
- Wait 10 to 15 minutes for the antidote to take effect. If you are able to ambulate, know who you are, and where you are, you will NOT need a second injection. Warning: Giving yourself a second set of injections may cause an overdose of the ATNAA which could result in incapacitation.
- If symptoms of nerve agent poisoning are not relieved after administering one injection, seek someone else to check your symptoms. A buddy must administer the second and third injections, if needed.
- Casualties with severe symptoms may experience most or all of the mild symptoms described above, plus most or all of the following:
- Strange or confused behavior
- Increased wheezing and increased difficulty in breathing
- Severely pinpointed pupils
- Red eyes with tearing
- Severe muscular twitching and general weakness
- Involuntary urination and defecation
- Respiratory failure
- If you encounter a service member suffering from severe signs of nerve agent poisoning, render the following aid:
- Mask the casualty, if necessary. Do not fasten the hood.
- If self-aid (one ATNAA) has been administered, administer, in rapid succession, two (2) additional ATNAAs into the casualty's lateral thigh muscle or buttocks.
Note: Use the casualty's own ATNAAs when providing aid. Do not use your own injectors on a casualty. If you do, you may not have any antidote available when needed for self-aid.
- If self-aid (one ATNAA) has not been administered, administer, in rapid succession, three (3) ATNAAs into the casualty's lateral thigh muscle or buttocks.
IMPORTANT: PHYSICIANS AND/OR MEDICAL PERSONNEL ASSISTING EVACUATED VICTIMS OF NERVE AGENTS, SHOULD AVOID EXPOSING THEMSELVES TO CONTAMINATION BY THE VICTIM'S CLOTHING.
More about ATNAA (atropine / pralidoxime)
- Other brands: DuoDote