Aminophylline Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Asthma - Acute

IV: (all dosages based on aminophylline-patient not receiving aminophylline or theophylline}
Loading dose:
6 mg/kg in 100 to 200 mL of IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose):
Otherwise healthy nonsmoking adult: 0.7 mg/kg/hr continuous intravenous infusion.
Young adult smoker: 0.9 mg/kg/hr continuous intravenous infusion.
Patient with cor pulmonale or congestive heart failure: 0.25 mg/kg/hr continuous intravenous infusion.

Oral: (Patient not receiving aminophylline or theophylline)
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose):
Otherwise healthy nonsmoking adult: 12.5 mg/kg/day in divided doses. Do not exceed 1,125 mg/day.
Young adult smoker: 19 mg/kg/day in divided doses.
Patient with cor pulmonale or congestive heart failure: 6.25 mg/kg/day in divided doses. Do not exceed 500 mg/day.

Usual Geriatric Dose for Asthma - Acute

IV: (all dosages based on aminophylline)
Patient not receiving aminophylline or theophylline:
Loading dose: 6 mg/kg in 100 to 200 mL of IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose): 0.2 to 0.3 mg/kg/hr continuous intravenous infusion.

Oral: Patient not receiving aminophylline or theophylline:
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose): 1.7 to 2 mg/kg orally every 8 hours.

Usual Pediatric Dose for Apnea of Prematurity

<= 4 weeks: (IV or oral, all dosages based on aminophylline):
Loading dose: (Patient not receiving aminophylline or theophylline): 5 to 6 mg/kg once - if IV, dilute in IV fluid and give intravenously once over 20 to 30 minutes.
Maintenance dose: 3 to 8 mg/kg/day divided every 6 to 12 hours.

Usual Pediatric Dose for Asthma - Acute

IV: (all dosages based on aminophylline and patient not receiving aminophylline or theophylline):
Loading dose:: 6 mg/kg diluted in IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose):
6 weeks to 6 months: 0.5 mg/kg/hour continuous intravenous infusion.
6 months to 1 year: 0.6 to 0.7 mg/kg/hr continuous intravenous infusion.
1 year to 9 years: 1 to 1.2 mg/kg/hr continuous intravenous infusion.
9 years to 12 years: 0.9 mg/kg/hr continuous intravenous infusion.
>12 years: 0.7 mg/kg/hr continuous intravenous infusion.

Oral: (Patient not receiving aminophylline or theophylline):
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose):
>=42 < 182 days: 12 to 13.5 mg/kg/day in divided doses.
>= 6 < 12 months: 15 to 22.5 mg/kg/day in divided doses.
>=1 year to <9 years: 25 to 30 mg/kg/day in divided doses.
>=9 years to <12 years: 17 to 20 mg/kg/day in divided doses.
>=12 to <16 years: 15 to 17 mg/kg in divided doses.
>=16 years: 6.25 to 20 mg/kg orally divided every 6 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Loading dose: 6 mg/kg (patient not receiving aminophylline or theophylline) diluted in IV fluid at a rate not more than 25 mg/min.
Maintenance dose: 0.25 mg/kg/hr continuous intravenous infusion.

Dose Adjustments

In patients receiving theophylline, each 0.5 mg/kg theophylline (0.6 mg/kg aminophylline) administered as a loading dose will increase serum theophylline level by 1 mcg/mL.

Dialysis

Aminophylline (theophylline) is somewhat removed with hemodialysis. A 50% supplemental dose or administering the dose post dialysis is recommended. A supplemental dose is not needed with peritoneal dialysis.

Other Comments

Serum levels may be obtained 15 to 30 minutes following an IV loading dose.

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