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Acetaminophen / Diphenhydramine / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Sep 6, 2023.

Applies to the following strengths: 320 mg-12.5 mg-5 mg/10 mL; 160 mg-6.25 mg-2.5 mg/5 mL; 650 mg-25 mg-10 mg/20 mL; 325 mg-12.5 mg-5 mg/15 mL; 650 mg-25 mg-10 mg; 500 mg-25 mg-10 mg; 650 mg-25 mg-10 mg/30 mL; 325 mg-12.5 mg-5 mg; 325 mg-25 mg-5 mg; 325 mg-12.5 mg-5 mg/10 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cold Symptoms

**Many different strength combinations and dosage forms are available. The manufacturer product information should be consulted.**

Acetaminophen 325 mg/ diphenhydramine 12.5 mg/ phenylephrine 5 mg per caplet: 2 caplets every 4 hours
Maximum dose: 5 doses (10 caplets) per 24 hours

Acetaminophen 325 mg/ diphenhydramine 25 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 500 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per packet: One packet every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per pod/packet: One pod/packet every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 20 mL: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 30 mL: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms

**Many different strength combinations and dosage forms are available. The manufacturer product information should be consulted.**

Acetaminophen 325 mg/ diphenhydramine 12.5 mg/ phenylephrine 5 mg per caplet:
12 years and older: 2 caplets every 4 hours
Maximum dose: 5 doses (10 caplets) per 24 hours

Acetaminophen 325 mg/ diphenhydramine 25 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 500 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per packet:
12 years and older: One packet every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per pod/packet:
12 years and older: One pod/packet every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 20 mL:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 30 mL:
12 years and older: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:



Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.