Acetadote Dosage
Generic name: acetylcysteine
Dosage form: injection, solution
This dosage information does not include all the information needed to use Acetadote safely and effectively. See full prescribing information for Acetadote.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
The total dose of Acetadote is 300 mg/kg administered over 21 hours. Please refer to the guidelines below for dose preparation based upon patient weight.
Administration Instructions (Three-Bag Method: Loading, Second and Third Dose)
Patients >40 kg (Table 1):
- Loading Dose: 150mg/kg in 200mL of diluent◊ administered over 60 min
- Second Dose: 50mg/kg in 500mL of diluent administered over 4 hr
- Third Dose: 100mg/kg in 1000mL of diluent administered over 16 hr
| Body Weight | LOADING Dose 150 mg/kg in |
SECOND Dose 50 mg/kg in |
THIRD Dose 100 mg/kg in |
|
| 200 mL diluent over 60 min | 500mL diluent over 4 hours | 1000mL diluent over 16 hours | ||
| (kg) | (lb) | Acetadote (mL) | Acetadote (mL) | Acetadote (mL) |
| 100 | 220 | 75 | 25 | 50 |
| 90 | 198 | 67.5 | 22.5 | 45 |
| 80 | 176 | 60 | 20 | 40 |
| 70 | 154 | 52.5 | 17.5 | 35 |
| 60 | 132 | 45 | 15 | 30 |
| 50 | 110 | 37.5 | 12.5 | 25 |
| 40 | 88 | 30 | 10 | 20 |
The total volume administered should be adjusted for patients less than 40 kg and for those requiring fluid restriction:
Patients >20 - <40 kg (Table 2):
- Loading Dose: 150 mg/kg in 100 mL of diluent◊ administered over 60 min
- Second Dose: 50 mg/kg in 250 mL of diluent administered over 4 hr
- Third Dose: 100 mg/kg in 500 mL of diluent administered over 16 hr
| Body Weight | LOADING Dose 150 mg/kg over 60 minutes |
SECOND Dose 50 mg/kg over 4 hours |
THIRD Dose 100 mg/kg over 16 hours |
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| (kg) | (lb) | Acetadote (mL) | Diluent◊ (mL) | Acetadote (mL) | Diluent (mL) | Acetadote (mL) | Diluent (mL) |
| 30 | 66 | 22.5 | 100 | 7.5 | 250 | 15 | 500 |
| 25 | 55 | 18.75 | 100 | 6.25 | 250 | 12.5 | 500 |
Patients <20 kg (Table 3):
- Loading Dose: 150mg/kg in 3mL/kg of body weight of diluent◊ administered over 60 min
- Second Dose: 50mg/kg in 7mL/kg of body weight of diluent administered over 4 hr
- Third Dose: 100mg/kg in 14mL/kg of body weight of diluent administered over 16 hr
|
◊Acetadote is hyperosmolar (2600 mOsm/L) and is compatible with 5% Dextrose (D5W), ½ Normal Saline (0.45% Sodium Chloride Injection, ½ NS), and Water for Injection (WFI). |
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| Body Weight | LOADING Dose 150 mg/kg over 60 minutes |
SECOND Dose 50 mg/kg over 4 hours |
THIRD Dose 100 mg/kg over 16 hours |
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| (kg) | (lb) | Acetadote (mL) | Diluent◊ (mL) | Acetadote (mL) | Diluent (mL) | Acetadote (mL) | Diluent (mL) |
| 20 | 44 | 15 | 60 | 5 | 140 | 10 | 280 |
| 15 | 33 | 11.25 | 45 | 3.75 | 105 | 7.5 | 210 |
| 10 | 22 | 7.5 | 30 | 2.5 | 70 | 5 | 140 |
Single dose vial, preservative-free, discard unused portion. If vial was previously opened, do not use for I.V. administration.
Stability studies indicate that the diluted solution is stable for 24 hours at controlled room temperature.
Note: The color of Acetadote may turn from essentially colorless to a slight pink or purple once the stopper is punctured. The color change does not affect the quality of the product.
Renal Impairment
No data are available to determine if a dose adjustment in patients with moderate or severe renal impairment is required.
Hepatic Impairment
Although there was a threefold increase in acetylcysteine plasma concentrations in patients with hepatic cirrhosis, no data are available to determine if a dose adjustment in these patients is required. The published medical literature does not indicate that the dose of acetylcysteine in patients with hepatic impairment should be reduced.
