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Abatacept Dosage

Medically reviewed by Drugs.com. Last updated on Mar 4, 2024.

Applies to the following strengths: 250 mg; 125 mg/mL; 50 mg/0.4 mL; 87.5 mg/0.7 mL

Usual Adult Dose for Rheumatoid Arthritis

IV Dosing Regimen:


Subcutaneous Dosing Regimen:

Comments:

Use: For the treatment of patients with moderately to severely active rheumatoid arthritis

Usual Adult Dose for Psoriatic Arthritis

IV Dosing Regimen:


Subcutaneous Dosing Regimen: 125 mg subcutaneously once a week

Comments:

Use: For the treatment of patients with active psoriatic arthritis

Usual Adult Dose for Graft Versus Host Disease - Prophylaxis

10 mg/kg IV on the day before transplantation (Day -1), then 10 mg/kg IV on Days 5, 14, and 28 after transplantation
Maximum dose: 1000 mg/dose

Comments:


Use: In combination with a calcineurin inhibitor and methotrexate, for the prophylaxis of acute graft versus host disease (aGVHD) in patients undergoing HSCT from a matched or 1 allele-mismatched unrelated-donor

Usual Pediatric Dose for Juvenile Idiopathic Arthritis

IV Dosing Regimen:
6 years or older:

Maximum dose: 1000 mg/dose

Subcutaneous Dosing Regimen:
2 years or older:

Comments:

Use: For the treatment of patients with moderately to severely active polyarticular juvenile idiopathic arthritis

Usual Pediatric Dose for Graft Versus Host Disease - Prophylaxis

2 to less than 6 years: 15 mg/kg IV on the day before transplantation (Day -1), then 12 mg/kg IV on Days 5, 14, and 28 after transplantation
6 years or older: 10 mg/kg IV on the day before transplantation (Day -1), then 10 mg/kg IV on Days 5, 14, and 28 after transplantation
Maximum dose: 1000 mg/dose

Comments:


Use: In combination with a calcineurin inhibitor and methotrexate, for the prophylaxis of aGVHD in patients undergoing HSCT from a matched or 1 allele-mismatched unrelated-donor

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
IV Infusion:

Subcutaneous Administration:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.