Sonata (zaleplon) Disease Interactions
There are 6 disease interactions with Sonata (zaleplon):
Anxiolytics/Sedatives/Hypnotics (Includes Sonata) ↔ Alcohol Intox
Severe Potential Hazard, High plausibility
Applies to: Alcoholism, Acute Alcohol Intoxication
Anxiolytic, sedative, and hypnotic agents should generally not be given to patients with acute alcohol intoxication exhibiting depressed vital signs. The central nervous system depressant effects of these agents may be additive with those of alcohol. Severe respiratory depression and death may occur. Therapy with such agents should be administered cautiously in patients who might be prone to acute alcohol intake.
Anxiolytics/Sedatives/Hypnotics (Includes Sonata) ↔ Drug Dependence
Severe Potential Hazard, High plausibility
Applies to: Alcoholism, Drug Abuse/Dependence
Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use of excessive dosages, and abrupt cessation and/or a reduction in dosage may precipitate withdrawal symptoms. In patients who have developed tolerance, overdosage can still produce respiratory depression and death. Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously and for as brief a period as possible. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance or medical supervision when treated with these agents. In addition, it may be prudent to refrain from dispensing large quantities of medication to such patients. After prolonged use or if dependency is suspected, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule.
Zaleplon (Includes Sonata) ↔ Liver Disease
Severe Potential Hazard, High plausibility
Applies to: Liver Disease
Zaleplon is primarily metabolized by the liver. The oral clearance of zaleplon has been shown to decrease by 70% and 87% in patients with compensated and decompensated cirrhosis, respectively, compared to healthy patients. Associated plasma drug concentrations were markedly increased by several-fold. Therapy with zaleplon is not recommended in patients with severely impaired hepatic function. The dosage should be reduced to 5 mg in patients with mild to moderate hepatic impairment.
Anxiolytics/Sedatives/Hypnotics (Includes Sonata) ↔ Depression
Moderate Potential Hazard, High plausibility
Applies to: Depression
Anxiolytic, sedative, and hypnotic agents depress the central nervous system and may cause or exacerbate mental depression. Therapy with these agents should be administered cautiously in patients with a history of depression or suicidal tendencies. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Anxiolytics/Sedatives/Hypnotics (Includes Sonata) ↔ Resp Depression
Moderate Potential Hazard, Moderate plausibility
Applies to: Asphyxia, Pulmonary Impairment, Respiratory Arrest, Sleep Apnea
Oral anxiolytic, sedative, and hypnotic agents may cause respiratory depression and apnea when given in high dosages or following acute overdose. However, some patients may be susceptible at commonly used dosages, including the elderly, debilitated or severely ill patients, those receiving other CNS depressants, and those with limited ventilatory reserve, chronic pulmonary insufficiency or other respiratory disorders. Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously in these patients. Appropriate monitoring and individualization of dosage are recommended.
Zaleplon (Includes Sonata) ↔ Renal Dysfunction
Moderate Potential Hazard, Low plausibility
Applies to: Renal Dysfunction
Zaleplon is excreted in the urine almost exclusively as metabolites and their glucuronides. The pharmacokinetics of zaleplon are not altered in patients with renal insufficiency. According to the manufacturer, dosage adjustments are not necessary in patients with mild to moderate renal impairment. However, caution may be appropriate if the drug is used in patients with severe renal impairment, since data establishing its safety and efficacy are lacking in such patients.
You should also know about...
Sonata (zaleplon) drug Interactions
There are 625 drug interactions with Sonata (zaleplon)
Sonata (zaleplon) alcohol/food Interactions
There are 2 alcohol/food interactions with Sonata (zaleplon)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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