Zafirlukast Disease Interactions

There is 1 disease interaction with zafirlukast:

The use of zafirlukast may be associated with elevations of one or more liver enzymes as well as life-threatening hepatic failure. Cases of liver injury without other attributable cause have been reported from postmarketing surveillance of patients treated with the recommended dosage of zafirlukast (40 mg/day). Although most cases have been reversible following drug discontinuation, fulminant hepatitis and progression to hepatic failure, liver transplantation, and death have been reported rarely. Zafirlukast is also primarily metabolized by the liver. In patients with hepatic cirrhosis, serum zafirlukast concentrations may be 50% to 60% higher than in normal patients. Because of the hepatotoxic effects, potential for accumulation, and lack of data regarding treatment in patients with hepatic impairment, therapy with zafirlukast should be administered cautiously in such patients. Periodic serum transaminase testing is recommended to enable early detection of drug-induced hepatic injury, and patients should be advised to contact their physician immediately if they experience signs or symptoms of liver dysfunction (e.g., right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, anorexia, and enlarged liver). Zafirlukast should be discontinued and liver function tests performed immediately if hepatic injury is suspected. The drug should not be resumed if hepatic injury is confirmed. Patients in whom zafirlukast was withdrawn because of hepatic injury where no other attributable cause is identified should not be re-exposed to zafirlukast.

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zafirlukast drug Interactions

There are 157 drug interactions with zafirlukast

zafirlukast food/lifestyle Interactions

There is 1 food/lifestyle interaction with zafirlukast

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