Yohimbine Disease Interactions
There are 5 disease interactions with yohimbine:
Yohimbine (Includes Yohimbine) ↔ Cardiovascular Disease
Severe Potential Hazard, High plausibility
Applies to: Hypertension, Heart Disease
Yohimbine can cause hypertension and tachycardia at recommended dosages. Large doses may cause hypotension and cardiac conduction disturbances. Therapy with yohimbine is generally not recommended in patients with hypertension, angina pectoris, or heart disease.
Yohimbine (Includes Yohimbine) ↔ Peptic Ulcer Disease
Severe Potential Hazard, High plausibility
Applies to: Peptic Ulcer, History - Peptic Ulcer
Yohimbine may increase gastric acid secretion and gastrointestinal motility secondary to its cholinergic activity. Therapy with yohimbine is generally not recommended in patients with a history of peptic ulcer disease.
Yohimbine (Includes Yohimbine) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
The use of yohimbine is contraindicated in patients with renal impairment. Yohimbine has mild antidiuretic effects, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone. Agents that reduce or suppress diuresis may aggravate renal diseases.
Yohimbine (Includes Yohimbine) ↔ Depression/Psychoses
Moderate Potential Hazard, Moderate plausibility
Applies to: Psychosis, Anxiety/Stress, Depression, History - Psychiatric Disorder
Yohimbine readily penetrates the blood-brain barrier and may cause anxiety, excitation, and other adverse nervous system effects. Precipitation or exacerbation of psychotic symptoms has been reported. Therapy with yohimbine should be administered cautiously in patients with anxiety, depression, or a history of psychiatric disorders.
Yohimbine (Includes Yohimbine) ↔ Liver Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
Data are limited concerning the use of yohimbine in patients with liver disease. Yohimbine is thought to undergo metabolism in the liver. Therapy with yohimbine should be administered cautiously in patients with significantly impaired hepatic function.
You should also know about...
yohimbine drug Interactions
There are 28 drug interactions with yohimbine
yohimbine alcohol/food Interactions
There is 1 alcohol/food interaction with yohimbine
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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