Yohimbe (yohimbine) Disease Interactions

There are 5 disease interactions with Yohimbe (yohimbine):

Yohimbine (Includes Yohimbe) ↔ Cardiovascular Disease

Severe Potential Hazard, High plausibility

Applies to: Hypertension, Heart Disease

Yohimbine can cause hypertension and tachycardia at recommended dosages. Large doses may cause hypotension and cardiac conduction disturbances. Therapy with yohimbine is generally not recommended in patients with hypertension, angina pectoris, or heart disease.

References

  1. Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
  2. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
  3. Grossman E, Rosenthal T, Peleg E, Holmes C, Goldstein DS "Oral yohimbine increases blood pressure and sympathetic nervous outflow in hypertensive patients." J Cardiovasc Pharmacol 22 (1993): 22-6
View all 4 references

Yohimbine (Includes Yohimbe) ↔ Peptic Ulcer Disease

Severe Potential Hazard, High plausibility

Applies to: Peptic Ulcer, History - Peptic Ulcer

Yohimbine may increase gastric acid secretion and gastrointestinal motility secondary to its cholinergic activity. Therapy with yohimbine is generally not recommended in patients with a history of peptic ulcer disease.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

Yohimbine (Includes Yohimbe) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of yohimbine is contraindicated in patients with renal impairment. Yohimbine has mild antidiuretic effects, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone. Agents that reduce or suppress diuresis may aggravate renal diseases.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

Yohimbine (Includes Yohimbe) ↔ Depression/Psychoses

Moderate Potential Hazard, Moderate plausibility

Applies to: Psychosis, Anxiety/Stress, Depression, History - Psychiatric Disorder

Yohimbine readily penetrates the blood-brain barrier and may cause anxiety, excitation, and other adverse nervous system effects. Precipitation or exacerbation of psychotic symptoms has been reported. Therapy with yohimbine should be administered cautiously in patients with anxiety, depression, or a history of psychiatric disorders.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

Yohimbine (Includes Yohimbe) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Data are limited concerning the use of yohimbine in patients with liver disease. Yohimbine is thought to undergo metabolism in the liver. Therapy with yohimbine should be administered cautiously in patients with significantly impaired hepatic function.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

You should also know about...

Yohimbe (yohimbine) drug Interactions

There are 29 drug interactions with Yohimbe (yohimbine)

Yohimbe (yohimbine) alcohol/food Interactions

There is 1 alcohol/food interaction with Yohimbe (yohimbine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2014 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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