Valacyclovir Disease Interactions

There are 3 disease interactions with valacyclovir:

Valacyclovir is almost completely converted in vivo to acyclovir, which is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for neuro- and nephrotoxicity (including further deterioration in renal function, tubular damage and acute renal failure) from acyclovir due to decreased drug clearance. Therapy with valacyclovir should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended in patients with moderate to severe renal dysfunction.

Cases of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) have been reported in patients with advanced HIV disease and in allogeneic bone marrow transplant and renal transplant recipients given valacyclovir 8 g/day during clinical trials. Although a causal relationship has not been established, therapy with valacyclovir should be administered cautiously in immunocompromised patients.

Valacyclovir is almost completely converted in vivo to acyclovir, which is substantially removed by hemodialysis. Plasma levels of acyclovir have been shown to reduce by 60% following 6 hours of dialysis. Valacyclovir should be administered after hemodialysis. Otherwise, an additional dose may be given after each hemodialysis session.

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valacyclovir drug Interactions

There are 18 drug interactions with valacyclovir

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