Tindamax (tinidazole) Disease Interactions
There are 5 disease interactions with Tindamax (tinidazole):
Nitroimidazoles (Includes Tindamax) ↔ Blood Dyscrasias
Severe Potential Hazard, Low plausibility
Applies to: Bone Marrow Depression/Low Blood Counts, History - Blood Dyscrasias
The use of nitroimidazoles (e.g., metronidazole, tinidazole) has rarely been associated with hematologic adverse effects such as mild, transient leukopenia, thrombocytopenia, and bone marrow aplasia. The manufacturers recommend that therapy with nitroimidazoles be administered cautiously in patients with evidence of or a history of blood dyscrasias, and that total and differential leukocyte counts be performed before and after treatment with these drugs, particularly in patients receiving repeated courses of therapy.
Nitroimidazoles (Includes Tindamax) ↔ Neurologic Toxicity
Severe Potential Hazard, Moderate plausibility
Applies to: CNS Disorder, Peripheral Neuropathy
The use of nitroimidazoles (e.g., metronidazole, tinidazole) has been associated with the development of nervous system toxicity including convulsive seizures and dose-related peripheral neuropathy, the latter characterized primarily by numbness or paresthesia of an extremity. Persistent peripheral neuropathy has been reported in some patients treated for prolonged periods. Other neurologic adverse effects include vertigo, incoordination, ataxia, confusion, agitation, hallucinations, and depression. Therapy with nitroimidazoles should be administered cautiously in patients with or predisposed to seizures or other nervous system abnormalities. Nitroimidazole therapy should be discontinued promptly if neurologic disturbances occur.
Metronidazole (Includes Tindamax) ↔ Alcoholism
Moderate Potential Hazard, Moderate plausibility
Applies to: Alcoholism
Nitroimidazoles (e.g., metronidazole, tinidazole) may inhibit alcohol dehydrogenase and occasionally precipitate a disulfiram-like reaction in patients who consume alcohol while being treated. Symptoms may include nausea, vomiting, flushing, sweating, headache, abdominal cramps, and hypotension. Patients should be instructed to avoid alcohol-containing products during nitroimidazole therapy and for at least 48 to 72 hours after the last dose. Therapy with nitroimidazoles should be administered cautiously in patients who might be prone to acute alcohol intake. An alternative therapy may be appropriate.
Tinidazole (Includes Tindamax) ↔ Hemodialysis
Moderate Potential Hazard, High plausibility
Applies to: hemodialysis
Tinidazole is removed by hemodialysis. During a 6-hour hemodialysis session, approximately 43% of the drug present in the body is eliminated, and the half-life is reduced from 12 hours to 4.9 hours. Therefore, on days when dialysis is performed, an additional dose of tinidazole equivalent to one-half the prescribed dose is recommended after the hemodialysis session.
Tinidazole (Includes Tindamax) ↔ Liver Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
There are no data on the pharmacokinetics of tinidazole in patients with impaired hepatic function. Reduction of metabolic elimination of metronidazole, a chemically-related drug, has been reported in patients with hepatic dysfunction. Since tinidazole is also extensively metabolized by the liver prior to excretion, therapy with tinidazole should be administered cautiously in the presence of severe liver disease.
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Tindamax (tinidazole) drug Interactions
There are 161 drug interactions with Tindamax (tinidazole)
Tindamax (tinidazole) alcohol/food Interactions
There is 1 alcohol/food interaction with Tindamax (tinidazole)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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