Serevent Diskus (salmeterol) Disease Interactions

There are 4 disease interactions with Serevent Diskus (salmeterol):

Adrenergic bronchodilators can stimulate cardiovascular beta-1 and beta-2 receptors, occasionally producing adverse effects such as tachycardia, palpitation, ECG changes, peripheral vasodilation, and blood pressure changes. Direct stimulation of cardiac tissues is mediated by beta-1 receptors and thus less likely to occur with beta-2-selective agents such as albuterol. However, beta-2-selectivity is not absolute and can be lost with larger doses. High dosages of these agents have been associated with precipitation or aggravation of angina, myocardial ischemia, and cardiac arrhythmias. Therapy with adrenergic bronchodilators should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism or underlying cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, or hypertension. The recommended dosages should not be exceeded. Systemic adverse effects are minimized but not abolished by administration of these agents via oral inhalation.

Adrenergic bronchodilators may cause increases in blood glucose concentrations. These effects are usually transient and slight but may be significant with dosages higher than those normally recommended. Large doses of IV albuterol (not commercially available in the U.S.) and terbutaline sulfate have been reported to exacerbate preexisting diabetes mellitus and ketoacidosis. Therapy with adrenergic bronchodilators should be administered cautiously in patients with diabetes mellitus. Closer monitoring of blood glucose concentrations may be appropriate.

Adrenergic bronchodilators may cause decreases in serum potassium concentrations, primarily when given by nebulization or intravenous administration. Although this effect is usually transient and does not require supplementation, clinically significant hypokalemia may occur in some patients, with the potential to induce cardiovascular adverse effects. The relevance of these observations to oral or oral aerosol/powder for inhalation therapy is unknown. Therapy with adrenergic bronchodilators should be administered cautiously in patients with or predisposed to hypokalemia.

Adrenergic bronchodilators may cause CNS stimulation. Seizures have been reported rarely in patients treated with terbutaline. Therapy with adrenergic bronchodilators should be administered cautiously in patients with seizure disorders. Systemic adverse effects are minimized but not abolished by administration of these agents via oral inhalation.

You should also know about...

Serevent Diskus (salmeterol) drug Interactions

There are 241 drug interactions with Serevent Diskus (salmeterol)

Serevent Diskus (salmeterol) food/lifestyle Interactions

There is 1 food/lifestyle interaction with Serevent Diskus (salmeterol)

See also...

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.