Flumadine (rimantadine) Disease Interactions
There are 3 disease interactions with Flumadine (rimantadine):
Rimantadine (Includes Flumadine) ↔ Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease
Rimantadine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with liver disease. One-half the usual dosage is recommended for patients with severe hepatic dysfunction.
Rimantadine (Includes Flumadine) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Rimantadine and its metabolites are excreted by the kidney. Patients with renal impairment may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with renal impairment. One-half the usual dosage is recommended for patients with severe renal dysfunction (CrCl <= 10 mL/min).
Rimantadine (Includes Flumadine) ↔ Seizure Disorders
Moderate Potential Hazard, Low plausibility
Applies to: Seizures
Seizures have been reported in a few patients with a history of seizure disorders who were not receiving anticonvulsant medication while taking rimantadine. Therapy with rimantadine should be administered cautiously in patients with epilepsy or predisposed to seizures.
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Flumadine (rimantadine) drug Interactions
There are 19 drug interactions with Flumadine (rimantadine)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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