Zantac (ranitidine) Disease Interactions
There are 5 disease interactions with Zantac (ranitidine):
Ranitidine (Includes Zantac) ↔ Porphyria
Severe Potential Hazard, Moderate plausibility
Applies to: Porphyria
Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.
Ranitidine (Includes Zantac) ↔ Hemodialysis
Moderate Potential Hazard, High plausibility
Applies to: hemodialysis
Ranitidine is partially removed by hemodialysis and should be administered after dialysis.
Ranitidine (Includes Zantac) ↔ Liver Disease
Moderate Potential Hazard, Low plausibility
Applies to: Liver Disease
Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.
Ranitidine (Includes Zantac) ↔ Pku
Moderate Potential Hazard, High plausibility
Applies to: Phenylketonuria
Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).
Ranitidine (Includes Zantac) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.
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Zantac (ranitidine) drug Interactions
There are 268 drug interactions with Zantac (ranitidine)
Zantac (ranitidine) alcohol/food Interactions
There is 1 alcohol/food interaction with Zantac (ranitidine)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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