Paroxetine Disease Interactions
There are 7 disease interactions with paroxetine:
Paroxetine (Includes Paroxetine) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Paroxetine may accumulate in renal dysfunction. The mean plasma concentration of paroxetine in patients with creatinine clearance below 30 mL/min has been shown to be approximately four times greater than that in normal patients. Therapy with paroxetine should be administered cautiously in patients with renal impairment. A reduction in the daily dosage is recommended if renal function is severely impaired.
Ssris (Includes Paroxetine) ↔ Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease
Selective serotonin reuptake inhibitors (SSRIs) are primarily metabolized by the liver. The plasma concentrations of SSRIs and their metabolites may be increased and the half-lives prolonged in patients with impaired hepatic function. Dosage adjustments may be necessary in accordance with the individual product package labeling.
Ssris (Includes Paroxetine) ↔ Mania
Moderate Potential Hazard, Moderate plausibility
Applies to: Mania, Bipolar Disorder
Selective serotonin reuptake inhibitors (SSRIs), like other antidepressants, may occasionally cause mania or hypomania. The reported incidence ranged from 0.1% to 2% in premarketing testing of several SSRIs. Patients with bipolar disorder are generally more likely to experience mania from antidepressants. Therapy with SSRIs should be administered cautiously in patients with a history of mania or bipolar disorder.
Ssris (Includes Paroxetine) ↔ Platelet Function
Moderate Potential Hazard, High plausibility
Applies to: Vitamin K Deficiency, Thrombocytopenia, Thrombocytopathy, Coagulation Defect, Bleeding
The use of selective serotonin reuptake inhibitors (SSRIs) has been associated with altered platelet function. Petechiae, purpura, ecchymosis, increased bleeding times, epistaxis and gastrointestinal hemorrhage have been reported. Therapy with SSRIs should be administered cautiously in patients with severe active bleeding or a hemorrhagic diathesis.
Ssris (Includes Paroxetine) ↔ Seizure Disorders
Moderate Potential Hazard, Moderate plausibility
Applies to: Seizures
Selective serotonin reuptake inhibitors (SSRIs) may trigger seizures in approximately 0.2% of patients. Therapy with SSRIs should be administered cautiously in patients with seizure disorders.
Ssris (Includes Paroxetine) ↔ Siadh
Moderate Potential Hazard, Moderate plausibility
Applies to: SIADH, Hyponatremia, Dehydration
The use of selective serotonin reuptake inhibitors (SSRIs) has rarely been associated with hyponatremia, sometimes secondary to development of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). These events have generally been reversible following discontinuation of SSRI therapy and/or medical intervention. SSRI-related hyponatremia may be more common in elderly female patients and those who are volume-depleted or receiving concomitant diuretic therapy. Caution may be warranted when SSRI therapy is administered in these patients and patients with preexisting hyponatremia or SIADH. Serum electrolytes, especially sodium as well as BUN and plasma creatinine, should be monitored regularly.
Ssris (Includes Paroxetine) ↔ Weight Loss
Minor Potential Hazard, Moderate plausibility
Applies to: Weight Loss/Failure to Thrive, Anorexia/Feeding Problems, Malnourished
The use of selective serotonin reuptake inhibitors (SSRIs) may occasionally cause significant weight loss, which may be undesirable in patients suffering from anorexia, malnutrition or excessive weight loss. Anorexia may occur in approximately 5% to 10% of patients. Weight change should be monitored during therapy if an SSRI is used in these patients.
You should also know about...
paroxetine drug Interactions
There are 831 drug interactions with paroxetine
paroxetine alcohol/food Interactions
There is 1 alcohol/food interaction with paroxetine
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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