Prozac (fluoxetine) Disease Interactions
There are 8 disease interactions with Prozac (fluoxetine):
Diabetes- Liver Disease
- Mania
- Platelet Function
- Seizure Disorders
- Siadh
- Renal Dysfunction
- Weight Loss
Fluoxetine (Includes Prozac) ↔ Diabetes
Moderate Potential Hazard, Moderate plausibility
Applies to: Diabetes Mellitus
Fluoxetine may alter blood glucose control in patients with diabetes. Hypoglycemia may occur during therapy with fluoxetine, and hyperglycemia may occur following discontinuation of the drug. Dosage adjustments in insulin and/or oral hypoglycemic medications may be necessary in patients with diabetes whenever fluoxetine therapy is initiated or discontinued.
Ssris (Includes Prozac) ↔ Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease
Selective serotonin reuptake inhibitors (SSRIs) are primarily metabolized by the liver. The plasma concentrations of SSRIs and their metabolites may be increased and the half-lives prolonged in patients with impaired hepatic function. Dosage adjustments may be necessary in accordance with the individual product package labeling.
Ssris (Includes Prozac) ↔ Mania
Moderate Potential Hazard, Moderate plausibility
Applies to: Mania, Bipolar Disorder
Selective serotonin reuptake inhibitors (SSRIs), like other antidepressants, may occasionally cause mania or hypomania. The reported incidence ranged from 0.1% to 2% in premarketing testing of several SSRIs. Patients with bipolar disorder are generally more likely to experience mania from antidepressants. Therapy with SSRIs should be administered cautiously in patients with a history of mania or bipolar disorder.
Ssris (Includes Prozac) ↔ Platelet Function
Moderate Potential Hazard, High plausibility
Applies to: Bleeding, Coagulation Defect, Thrombocytopathy, Thrombocytopenia, Vitamin K Deficiency
The use of selective serotonin reuptake inhibitors (SSRIs) has been associated with altered platelet function. Petechiae, purpura, ecchymosis, increased bleeding times, epistaxis and gastrointestinal hemorrhage have been reported. Therapy with SSRIs should be administered cautiously in patients with severe active bleeding or a hemorrhagic diathesis.
Ssris (Includes Prozac) ↔ Seizure Disorders
Moderate Potential Hazard, Moderate plausibility
Applies to: Seizures
Selective serotonin reuptake inhibitors (SSRIs) may trigger seizures in approximately 0.2% of patients. Therapy with SSRIs should be administered cautiously in patients with seizure disorders.
Ssris (Includes Prozac) ↔ Siadh
Moderate Potential Hazard, Moderate plausibility
Applies to: Dehydration, Hyponatremia, SIADH
The use of selective serotonin reuptake inhibitors (SSRIs) has rarely been associated with hyponatremia, sometimes secondary to development of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). These events have generally been reversible following discontinuation of SSRI therapy and/or medical intervention. SSRI-related hyponatremia may be more common in elderly female patients and those who are volume-depleted or receiving concomitant diuretic therapy. Caution may be warranted when SSRI therapy is administered in these patients and patients with preexisting hyponatremia or SIADH. Serum electrolytes, especially sodium as well as BUN and plasma creatinine, should be monitored regularly.
Fluoxetine (Includes Prozac) ↔ Renal Dysfunction
Minor Potential Hazard, Low plausibility
Applies to: Renal Dysfunction
Fluoxetine is primarily metabolized by the liver. All but one metabolites are inactive, and they are excreted by the kidney. The clearance of norfluoxetine, the active metabolite, is not dependent on renal function. Dosage adjustments are generally not deemed necessary in patients with impaired renal function, although the clinical significance of possible metabolite accumulation is unknown. Caution may be warranted when fluoxetine therapy is administered in patients with severe renal dysfunction.
Ssris (Includes Prozac) ↔ Weight Loss
Minor Potential Hazard, Moderate plausibility
Applies to: Weight Loss/Failure to Thrive, Malnourished, Anorexia/Feeding Problems
The use of selective serotonin reuptake inhibitors (SSRIs) may occasionally cause significant weight loss, which may be undesirable in patients suffering from anorexia, malnutrition or excessive weight loss. Anorexia may occur in approximately 5% to 10% of patients. Weight change should be monitored during therapy if an SSRI is used in these patients.
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Prozac (fluoxetine) drug Interactions
There are 838 drug interactions with Prozac (fluoxetine)
Prozac (fluoxetine) alcohol/food Interactions
There is 1 alcohol/food interaction with Prozac (fluoxetine)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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