Nexium (esomeprazole) Disease Interactions
There is 1 disease interaction with Nexium (esomeprazole):
Esomeprazole (Includes Nexium) ↔ Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease
Esomeprazole is primarily metabolized by the liver. In patients with mild to moderate hepatic impairment (Child Pugh Class A and B), little drug accumulation has been observed following once-daily, multiple-dose administration. No dosage adjustments are necessary in these patients. In severe hepatic impairment (Child Pugh Class C), however, substantial increases in plasma drug concentrations have been demonstrated. The manufacturer recommends a maximum dosage of 20 mg once daily in patients with severe liver disease.
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Nexium (esomeprazole) drug Interactions
There are 237 drug interactions with Nexium (esomeprazole)
Nexium (esomeprazole) alcohol/food Interactions
There is 1 alcohol/food interaction with Nexium (esomeprazole)
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Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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