Catapres (clonidine) Disease Interactions
There are 4 disease interactions with Catapres (clonidine):
Alpha-2 Agonists (Central) (Includes Catapres) ↔ Bradyarrhythmia
Moderate Potential Hazard, High plausibility
Applies to: Heart Block, Sinus Node Dysfunction
Central alpha-2 adrenoreceptor agonists reduce sympathetic outflow from the central nervous system. Heart rate is decreased, which may lead to or exacerbate sinus bradycardia and atrioventricular block. Therapy with central alpha-2 adrenoreceptor agonists should be administered cautiously in patients with conduction disturbances such as sinus node dysfunction or AV nodal disease.
Alpha-2 Agonists (Central) (Includes Catapres) ↔ Depression
Moderate Potential Hazard, Moderate plausibility
Applies to: Depression
Central alpha-2 adrenoreceptor agonists may occasionally cause mental depression and should be used cautiously in patients with a history of depression.
Alpha-2 Agonists (Central) (Includes Catapres) ↔ Hypotension
Moderate Potential Hazard, High plausibility
Applies to: Hypotension, Ischemic Heart Disease, Peripheral Arterial Disease, Cerebrovascular Insufficiency
Central alpha-2 adrenoreceptor agonists reduce sympathetic outflow from the central nervous system, resulting in decreases in heart rate, peripheral and renovascular resistance, and blood pressure. Therapy with these agents should be administered cautiously in patients with hypotension or conditions that may be exacerbated by decreased blood pressure and perfusion, such as coronary insufficiency, peripheral vascular disease (e.g., Raynaud's syndrome), cerebrovascular disease, or recent myocardial infarction.
Clonidine (Includes Catapres) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Clonidine is primarily eliminated unchanged by the kidney. The serum concentrations and half-life of clonidine may be increased in patients with impaired renal function. Dosage adjustments may be necessary and modifications should be based on the degree of renal impairment.
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Catapres (clonidine) drug Interactions
There are 621 drug interactions with Catapres (clonidine)
Catapres (clonidine) alcohol/food Interactions
There is 1 alcohol/food interaction with Catapres (clonidine)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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