Tagamet (cimetidine) Disease Interactions

There are 3 disease interactions with Tagamet (cimetidine):

Cimetidine is partially metabolized by the liver, and to a greater extent when administered orally than when given intravenously. Although dosage reductions are generally not necessary, therapy with cimetidine should be administered cautiously in patients with liver disease. Hepatotoxicity has been associated with cimetidine use. In addition, liver disease appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are usually reversible within 3 to 4 days after discontinuation of therapy.

Cimetidine is partially removed by hemodialysis and should be administered after dialysis.

Cimetidine and its metabolites are primarily eliminated by the kidney. The daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution. Renal dysfunction also appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are generally reversible within 3 to 4 days after discontinuation of therapy.

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Tagamet (cimetidine) drug Interactions

There are 601 drug interactions with Tagamet (cimetidine)

Tagamet (cimetidine) food/lifestyle Interactions

There are 3 food/lifestyle interactions with Tagamet (cimetidine)

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